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3ckx

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(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_3ckx", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
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[[Image:3ckx.jpg|left|200px]]
 
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==Crystal structure of sterile 20-like kinase 3 (MST3, STK24) in complex with staurosporine==
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The line below this paragraph, containing "STRUCTURE_3ckx", creates the "Structure Box" on the page.
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<StructureSection load='3ckx' size='340' side='right'caption='[[3ckx]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ckx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CKX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=STU:STAUROSPORINE'>STU</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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{{STRUCTURE_3ckx| PDB=3ckx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ckx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckx OCA], [https://pdbe.org/3ckx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ckx RCSB], [https://www.ebi.ac.uk/pdbsum/3ckx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ckx ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3ckx TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/STK24_HUMAN STK24_HUMAN] Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.<ref>PMID:16314523</ref> <ref>PMID:17046825</ref> <ref>PMID:19604147</ref> <ref>PMID:19855390</ref> <ref>PMID:19782762</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/3ckx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ckx ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of sterile 20-like kinase 3 (MST3, STK24) in complex with staurosporine'''
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3CKX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKX OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Antonysamy SS]]
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[[Category: Antonysamy, S S.]]
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[[Category: Buchanan S]]
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[[Category: Buchanan, S.]]
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[[Category: Burley SK]]
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[[Category: Burley, S K.]]
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[[Category: Chau F]]
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[[Category: Chau, F.]]
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[[Category: Feil I]]
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[[Category: Feil, I.]]
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[[Category: Sauder JM]]
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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[[Category: Wu L]]
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[[Category: Sauder, J M.]]
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[[Category: Wu, L.]]
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[[Category: Alternative splicing]]
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[[Category: Atp-binding]]
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[[Category: Cytoplasm]]
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[[Category: Mst3]]
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[[Category: New york structural genomix research consortium]]
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[[Category: Nucleotide-binding]]
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[[Category: Nysgxrc]]
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[[Category: Phosphoprotein]]
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[[Category: Protein kinase]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Staurosporine]]
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[[Category: Sterile 20-like kinase]]
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[[Category: Stk24]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:37:19 2008''
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Current revision

Crystal structure of sterile 20-like kinase 3 (MST3, STK24) in complex with staurosporine

PDB ID 3ckx

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