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3cos

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[[Image:3cos.png|left|200px]]
 
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{{STRUCTURE_3cos| PDB=3cos | SCENE= }}
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==Crystal structure of human class II alcohol dehydrogenase (ADH4) in complex with NAD and Zn==
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<StructureSection load='3cos' size='340' side='right'caption='[[3cos]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Crystal structure of human class II alcohol dehydrogenase (ADH4) in complex with NAD and Zn===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3cos]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3COS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[3cos]] is a 4 chain structure of [[Alcohol dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COS OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cos OCA], [https://pdbe.org/3cos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cos RCSB], [https://www.ebi.ac.uk/pdbsum/3cos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cos ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ADH4_HUMAN ADH4_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/3cos_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cos ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Alcohol dehydrogenase|Alcohol dehydrogenase]]
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*[[Alcohol dehydrogenase 3D structures|Alcohol dehydrogenase 3D structures]]
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[[Category: Alcohol dehydrogenase]]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bishop, S.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bishop S]]
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[[Category: Delft, F von.]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Kavanagh, K L.]]
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[[Category: Kavanagh KL]]
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[[Category: Murray, J.]]
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[[Category: Murray J]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann U]]
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[[Category: Roos, A.]]
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[[Category: Roos A]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Shafqat N]]
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[[Category: Shafqat, N.]]
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[[Category: Yue W]]
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[[Category: Yue, W.]]
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[[Category: Von Delft F]]
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[[Category: Alcohol dehydrogenase]]
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[[Category: Medium chain dehydrogenase]]
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[[Category: Metal-binding]]
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[[Category: Nad]]
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[[Category: Oxidoreductase]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Zinc-dependent]]
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Current revision

Crystal structure of human class II alcohol dehydrogenase (ADH4) in complex with NAD and Zn

PDB ID 3cos

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