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3cqo

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Crystal structure of a f-lectin (fucolectin) from morone saxatilis (striped bass) serum

Structural highlights

3cqo is a 3 chain structure with sequence from Morone saxatilis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.32Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q2LK81_MORSA

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The plasma of the striped bass Morone saxatilis contains a fucose-specific lectin (MsaFBP32) that consists of two F-type carbohydrate recognition domains (CRDs) in tandem. The crystal structure of the complex of MsaFBP32 with l-fucose reported here shows a cylindrical 81-A-long and 60-A-wide trimer divided into two globular halves: one containing N-terminal CRDs (N-CRDs) and the other containing C-terminal CRDs (C-CRDs). The resulting binding surfaces at the opposite ends of the cylindrical trimer have the potential to cross-link cell surface or humoral carbohydrate ligands. The N-CRDs and C-CRDs of MsaFBP32 exhibit significant structural differences, suggesting that they recognize different glycans. Analysis of the carbohydrate binding sites provides the structural basis for the observed specificity of MsaFBP32 for simple carbohydrates and suggests that the N-CRD recognizes more complex fucosylated oligosaccharides and with a relatively higher avidity than the C-CRD. Modeling of MsaFBP32 complexed with fucosylated glycans that are widely distributed in prokaryotes and eukaryotes rationalizes the observation that binary tandem CRD F-type lectins function as opsonins by cross-linking "non-self" carbohydrate ligands and "self" carbohydrate ligands, such as sugar structures displayed by microbial pathogens and glycans on the surface of phagocytic cells from the host.

Structure and specificity of a binary tandem domain F-lectin from striped bass (Morone saxatilis).,Bianchet MA, Odom EW, Vasta GR, Amzel LM J Mol Biol. 2010 Aug 13;401(2):239-52. Epub 2010 Jun 16. PMID:20561530^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Bianchet MA, Odom EW, Vasta GR, Amzel LM. Structure and specificity of a binary tandem domain F-lectin from striped bass (Morone saxatilis). J Mol Biol. 2010 Aug 13;401(2):239-52. Epub 2010 Jun 16. PMID:20561530 doi:10.1016/j.jmb.2010.06.018

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3cqo"

Categories: Large Structures | Morone saxatilis | Amzel LM | Bianchet MA

@@ Line 1: / Line 1: @@
 ==Crystal structure of a f-lectin (fucolectin) from morone saxatilis (striped bass) serum==
-<StructureSection load='3cqo' size='340' side='right' caption='[[3cqo]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
+<StructureSection load='3cqo' size='340' side='right'caption='[[3cqo]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3cqo]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Morone_saxatilis Morone saxatilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CQO FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3cqo]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Morone_saxatilis Morone saxatilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CQO FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k12|1k12]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cqo OCA], [http://pdbe.org/3cqo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cqo RCSB], [http://www.ebi.ac.uk/pdbsum/3cqo PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cqo OCA], [https://pdbe.org/3cqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cqo RCSB], [https://www.ebi.ac.uk/pdbsum/3cqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cqo ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q2LK81_MORSA Q2LK81_MORSA]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cq/3cqo_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cq/3cqo_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 30: / Line 33: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Morone saxatilis]]
-[[Category: Amzel, L M]]
+[[Category: Amzel LM]]
-[[Category: Bianchet, M A]]
+[[Category: Bianchet MA]]
-[[Category: F-lectin]]
-[[Category: Fucolectin]]
-[[Category: Sugar binding protein]]

3cqo

From Proteopedia

Current revision

Crystal structure of a f-lectin (fucolectin) from morone saxatilis (striped bass) serum

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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