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3cxm

From Proteopedia

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(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_3cxm", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
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[[Image:3cxm.png|left|200px]]
 
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==Leishmania naiffi uracil-DNA glycosylase in complex with 5-bromouracil==
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The line below this paragraph, containing "STRUCTURE_3cxm", creates the "Structure Box" on the page.
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<StructureSection load='3cxm' size='340' side='right'caption='[[3cxm]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cxm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_naiffi Leishmania naiffi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CXM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=URA:URACIL'>URA</scene>, <scene name='pdbligand=URB:5-BROMOPYRIMIDINE-2,4(1H,3H)-DIONE'>URB</scene></td></tr>
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{{STRUCTURE_3cxm| PDB=3cxm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxm OCA], [https://pdbe.org/3cxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cxm RCSB], [https://www.ebi.ac.uk/pdbsum/3cxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cxm ProSAT]</span></td></tr>
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</table>
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===Leishmania naiffi uracil-DNA glycosylase in complex with 5-bromouracil===
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== Function ==
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[https://www.uniprot.org/uniprot/D0VWU0_9TRYP D0VWU0_9TRYP] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.[HAMAP-Rule:MF_03166][RuleBase:RU003780]
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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[[3cxm]] is a 1 chain structure of [[DNA glycosylate]] with sequence from [http://en.wikipedia.org/wiki/Leishmania_naiffi Leishmania naiffi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXM OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/3cxm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cxm ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA glycosylate|DNA glycosylate]]
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Leishmania naiffi]]
[[Category: Leishmania naiffi]]
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[[Category: Larson, E T.]]
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[[Category: Larson ET]]
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[[Category: Merritt, E A.]]
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[[Category: Merritt EA]]
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[[Category: SGPP, Structural Genomics of Pathogenic Protozoa Consortium.]]
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[[Category: 5-bromouracil]]
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[[Category: Base excision repair]]
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[[Category: Ber]]
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[[Category: Dna damage repair]]
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[[Category: Dna repair]]
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[[Category: Glycosidase]]
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[[Category: Glycosylase]]
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[[Category: Hydrolase]]
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[[Category: Leishmania]]
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[[Category: Msgpp]]
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[[Category: Sgpp]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics of pathogenic protozoa consortium]]
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Current revision

Leishmania naiffi uracil-DNA glycosylase in complex with 5-bromouracil

PDB ID 3cxm

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