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3d1g

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==Structure of a small molecule inhibitor bound to a DNA sliding clamp==
==Structure of a small molecule inhibitor bound to a DNA sliding clamp==
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<StructureSection load='3d1g' size='340' side='right' caption='[[3d1g]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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<StructureSection load='3d1g' size='340' side='right'caption='[[3d1g]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3d1g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D1G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3d1g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D1G FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=322:[(5R)-5-(2,3-DIBROMO-5-ETHOXY-4-HYDROXYBENZYL)-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]ACETIC+ACID'>322</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2pol|2pol]], [[3bep|3bep]], [[3d1e|3d1e]], [[3d1f|3d1f]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=322:[(5R)-5-(2,3-DIBROMO-5-ETHOXY-4-HYDROXYBENZYL)-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]ACETIC+ACID'>322</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dnaN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d1g OCA], [https://pdbe.org/3d1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d1g RCSB], [https://www.ebi.ac.uk/pdbsum/3d1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d1g ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d1g OCA], [http://pdbe.org/3d1g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3d1g RCSB], [http://www.ebi.ac.uk/pdbsum/3d1g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3d1g ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.
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[https://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d1/3d1g_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d1/3d1g_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3d1g" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3d1g" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Escherichia coli K-12]]
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Donnell, M O]]
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[[Category: Georgescu RE]]
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[[Category: Georgescu, R E]]
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[[Category: Kong X-P]]
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[[Category: Kong, X-P]]
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[[Category: Kuriyan J]]
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[[Category: Kuriyan, J]]
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[[Category: O'Donnell M]]
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[[Category: Seung-Sup, K]]
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[[Category: Seung-Sup K]]
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[[Category: Yurieva, O]]
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[[Category: Yurieva O]]
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[[Category: Antibiotic target]]
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[[Category: Chemical probe]]
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[[Category: Dna polymerase]]
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[[Category: Dna replication]]
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[[Category: Dna sliding clamp]]
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[[Category: Rational drug design]]
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[[Category: Transcription]]
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[[Category: Transferase]]
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Current revision

Structure of a small molecule inhibitor bound to a DNA sliding clamp

PDB ID 3d1g

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