This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3d8b
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Crystal structure of human fidgetin-like protein 1 in complex with ADP== | ==Crystal structure of human fidgetin-like protein 1 in complex with ADP== | ||
| - | <StructureSection load='3d8b' size='340' side='right' caption='[[3d8b]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='3d8b' size='340' side='right'caption='[[3d8b]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3d8b]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3d8b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D8B FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d8b OCA], [https://pdbe.org/3d8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d8b RCSB], [https://www.ebi.ac.uk/pdbsum/3d8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d8b ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/FIGL1_HUMAN FIGL1_HUMAN] Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation.<ref>PMID:23754376</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d8/3d8b_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d8/3d8b_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 23: | Line 24: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Andersson J]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Berglund | + | [[Category: Berglund H]] |
| - | [[Category: Busam | + | [[Category: Busam RD]] |
| - | [[Category: Collins | + | [[Category: Collins R]] |
| - | [[Category: Dahlgren | + | [[Category: Dahlgren LG]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Flodin | + | [[Category: Flodin S]] |
| - | [[Category: Flores | + | [[Category: Flores A]] |
| - | [[Category: Graslund | + | [[Category: Graslund S]] |
| - | [[Category: Hammarstrom | + | [[Category: Hammarstrom M]] |
| - | [[Category: Johansson | + | [[Category: Johansson A]] |
| - | [[Category: Johansson | + | [[Category: Johansson I]] |
| - | [[Category: Kallas | + | [[Category: Kallas A]] |
| - | [[Category: Karlberg | + | [[Category: Karlberg T]] |
| - | [[Category: Kotenyova | + | [[Category: Kotenyova T]] |
| - | [[Category: Lehtio | + | [[Category: Lehtio L]] |
| - | [[Category: Moche | + | [[Category: Moche M]] |
| - | [[Category: Nilsson | + | [[Category: Nilsson ME]] |
| - | [[Category: Nordlund | + | [[Category: Nordlund P]] |
| - | [[Category: Nyman | + | [[Category: Nyman T]] |
| - | [[Category: Olesen | + | [[Category: Olesen K]] |
| - | [[Category: Persson | + | [[Category: Persson C]] |
| - | + | [[Category: Sagemark J]] | |
| - | [[Category: Sagemark | + | [[Category: Schuler H]] |
| - | [[Category: Schuler | + | [[Category: Thorsell AG]] |
| - | [[Category: Thorsell | + | [[Category: Tresaugues L]] |
| - | [[Category: Tresaugues | + | [[Category: Van Den Berg S]] |
| - | [[Category: | + | [[Category: Welin M]] |
| - | [[Category: | + | [[Category: Wikstrom M]] |
| - | [[Category: | + | [[Category: Wisniewska M]] |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal structure of human fidgetin-like protein 1 in complex with ADP
| |||||||||||
Categories: Homo sapiens | Large Structures | Andersson J | Arrowsmith CH | Berglund H | Busam RD | Collins R | Dahlgren LG | Edwards AM | Flodin S | Flores A | Graslund S | Hammarstrom M | Johansson A | Johansson I | Kallas A | Karlberg T | Kotenyova T | Lehtio L | Moche M | Nilsson ME | Nordlund P | Nyman T | Olesen K | Persson C | Sagemark J | Schuler H | Thorsell AG | Tresaugues L | Van Den Berg S | Welin M | Wikstrom M | Wisniewska M
