3d8b
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human fidgetin-like protein 1 in complex with ADP== | |
| - | + | <StructureSection load='3d8b' size='340' side='right'caption='[[3d8b]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3d8b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D8B FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d8b OCA], [https://pdbe.org/3d8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d8b RCSB], [https://www.ebi.ac.uk/pdbsum/3d8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d8b ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FIGL1_HUMAN FIGL1_HUMAN] Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation.<ref>PMID:23754376</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d8/3d8b_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d8b ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Andersson J]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Berglund H]] | ||
| + | [[Category: Busam RD]] | ||
| + | [[Category: Collins R]] | ||
| + | [[Category: Dahlgren LG]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Flodin S]] | ||
| + | [[Category: Flores A]] | ||
| + | [[Category: Graslund S]] | ||
| + | [[Category: Hammarstrom M]] | ||
| + | [[Category: Johansson A]] | ||
| + | [[Category: Johansson I]] | ||
| + | [[Category: Kallas A]] | ||
| + | [[Category: Karlberg T]] | ||
| + | [[Category: Kotenyova T]] | ||
| + | [[Category: Lehtio L]] | ||
| + | [[Category: Moche M]] | ||
| + | [[Category: Nilsson ME]] | ||
| + | [[Category: Nordlund P]] | ||
| + | [[Category: Nyman T]] | ||
| + | [[Category: Olesen K]] | ||
| + | [[Category: Persson C]] | ||
| + | [[Category: Sagemark J]] | ||
| + | [[Category: Schuler H]] | ||
| + | [[Category: Thorsell AG]] | ||
| + | [[Category: Tresaugues L]] | ||
| + | [[Category: Van Den Berg S]] | ||
| + | [[Category: Welin M]] | ||
| + | [[Category: Wikstrom M]] | ||
| + | [[Category: Wisniewska M]] | ||
Current revision
Crystal structure of human fidgetin-like protein 1 in complex with ADP
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Categories: Homo sapiens | Large Structures | Andersson J | Arrowsmith CH | Berglund H | Busam RD | Collins R | Dahlgren LG | Edwards AM | Flodin S | Flores A | Graslund S | Hammarstrom M | Johansson A | Johansson I | Kallas A | Karlberg T | Kotenyova T | Lehtio L | Moche M | Nilsson ME | Nordlund P | Nyman T | Olesen K | Persson C | Sagemark J | Schuler H | Thorsell AG | Tresaugues L | Van Den Berg S | Welin M | Wikstrom M | Wisniewska M
