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3dha

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Current revision (12:47, 30 August 2023) (edit) (undo)
 
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<StructureSection load='3dha' size='340' side='right'caption='[[3dha]], [[Resolution|resolution]] 0.95&Aring;' scene=''>
<StructureSection load='3dha' size='340' side='right'caption='[[3dha]], [[Resolution|resolution]] 0.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3dha]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bactk Bactk]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DHA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3dha]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thuringiensis_serovar_kurstaki Bacillus thuringiensis serovar kurstaki]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DHA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C6L:N-HEXANOYL-L-HOMOSERINE'>C6L</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2a7m|2a7m]], [[2r2d|2r2d]], [[3dhb|3dhb]], [[3dhc|3dhc]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C6L:N-HEXANOYL-L-HOMOSERINE'>C6L</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aiiA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29339 BACTK])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dha OCA], [https://pdbe.org/3dha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dha RCSB], [https://www.ebi.ac.uk/pdbsum/3dha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dha ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dha OCA], [https://pdbe.org/3dha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dha RCSB], [https://www.ebi.ac.uk/pdbsum/3dha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dha ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/AHLLA_BACTK AHLLA_BACTK]] Catalyzes hydrolysis of N-hexanoyl-(S)-homoserine lactone, but not the R-enantiomer. Hydrolyzes short- and long-chain N-acyl homoserine lactones with or without 3-oxo substitution at C3, has maximum activity on C10-AHL.<ref>PMID:16314577</ref>
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[https://www.uniprot.org/uniprot/AHLLA_BACTK AHLLA_BACTK] Catalyzes hydrolysis of N-hexanoyl-(S)-homoserine lactone, but not the R-enantiomer. Hydrolyzes short- and long-chain N-acyl homoserine lactones with or without 3-oxo substitution at C3, has maximum activity on C10-AHL.<ref>PMID:16314577</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bactk]]
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[[Category: Bacillus thuringiensis serovar kurstaki]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Fast, W]]
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[[Category: Fast W]]
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[[Category: Liu, D]]
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[[Category: Liu D]]
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[[Category: Momb, J]]
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[[Category: Momb J]]
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[[Category: Moulin, A]]
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[[Category: Moulin A]]
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[[Category: Petsko, G A]]
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[[Category: Petsko GA]]
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[[Category: Ringe, D]]
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[[Category: Ringe D]]
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[[Category: Thomas, P W]]
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[[Category: Thomas PW]]
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[[Category: Ahl lactonase]]
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[[Category: Alternative binding site]]
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[[Category: Hydrolase]]
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[[Category: N-acyl homoserine lactone]]
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[[Category: Product complex]]
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[[Category: Quorum quenching]]
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[[Category: Zinc bimetallohydrolase]]
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Current revision

An Ultral High Resolution Structure of N-Acyl Homoserine Lactone Hydrolase with the Product N-Hexanoyl-L-Homoserine Bound at An Alternative Site

PDB ID 3dha

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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