3dsq

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{{Seed}}
 
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[[Image:3dsq.png|left|200px]]
 
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==Structure of Desulfitobacterium hafniense PylSc, a pyrrolysyl tRNA synthetase==
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The line below this paragraph, containing "STRUCTURE_3dsq", creates the "Structure Box" on the page.
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<StructureSection load='3dsq' size='340' side='right'caption='[[3dsq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3dsq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfitobacterium_hafniense Desulfitobacterium hafniense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DSQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_3dsq| PDB=3dsq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dsq OCA], [https://pdbe.org/3dsq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dsq RCSB], [https://www.ebi.ac.uk/pdbsum/3dsq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dsq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B0S4P3_DESHA B0S4P3_DESHA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/3dsq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dsq ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pyrrolysine, the 22nd genetically-encoded amino acid, is charged onto its specific tRNA by PylS, a pyrrolysyl-tRNA synthetase. While PylS is found as a single protein in certain archaeal methanogens, in the gram-positive bacterium Desulfitobacterium hafniense, PylS is divided into two separate proteins, PylSn and PylSc, corresponding to the N-terminal and C-terminal domains of the single PylS protein found in methanogens. Previous crystallographic studies have provided the structure of a truncated C-terminal portion of the archaeal Methanosarcina mazei PylS associated with catalysis. Here, we report the apo 2.1A resolution structure of the intact D. hafniense PylSc protein and compare it to structures of the C-terminal truncated PylS from methanogenic species. In PylSc, the hydrophobic pocket binding the ring of pyrrolysine is more constrained than in the archaeal enzyme; other structural differences are also apparent.
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===Structure of Desulfitobacterium hafniense PylSc, a pyrrolysyl tRNA synthetase===
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Structure of Desulfitobacterium hafniense PylSc, a pyrrolysyl-tRNA synthetase.,Lee MM, Jiang R, Jain R, Larue RC, Krzycki J, Chan MK Biochem Biophys Res Commun. 2008 Sep 26;374(3):470-4. Epub 2008 Jul 24. PMID:18656445<ref>PMID:18656445</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3dsq" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18656445}}, adds the Publication Abstract to the page
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18656445 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18656445}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3DSQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Desulfitobacterium_hafniense Desulfitobacterium hafniense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DSQ OCA].
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==Reference==
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Structure of Desulfitobacterium hafniense PylSc, a pyrrolysyl-tRNA synthetase., Lee MM, Jiang R, Jain R, Larue RC, Krzycki J, Chan MK, Biochem Biophys Res Commun. 2008 Sep 26;374(3):470-4. Epub 2008 Jul 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18656445 18656445]
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[[Category: Desulfitobacterium hafniense]]
[[Category: Desulfitobacterium hafniense]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Chan, M K.]]
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[[Category: Chan MK]]
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[[Category: Lee, M M.]]
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[[Category: Lee MM]]
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[[Category: Aminoacyl-trna synthetase]]
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[[Category: Homodimer]]
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[[Category: Ligase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 10 09:06:49 2008''
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Current revision

Structure of Desulfitobacterium hafniense PylSc, a pyrrolysyl tRNA synthetase

PDB ID 3dsq

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