This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3dva

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:53, 30 August 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Snapshots of catalysis in the E1 subunit of the pyruvate dehydrogenase multi-enzyme complex==
==Snapshots of catalysis in the E1 subunit of the pyruvate dehydrogenase multi-enzyme complex==
-
<StructureSection load='3dva' size='340' side='right' caption='[[3dva]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
+
<StructureSection load='3dva' size='340' side='right'caption='[[3dva]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3dva]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_stearothermophilus Bacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DVA FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3dva]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DVA FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPW:2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-3-METHYLTHIOPHEN-2-YL}ETHYL+TRIHYDROGEN+DIPHOSPHATE'>TPW</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1w85|1w85]], [[1w88|1w88]], [[3duf|3duf]], [[3dv0|3dv0]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPW:2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-3-METHYLTHIOPHEN-2-YL}ETHYL+TRIHYDROGEN+DIPHOSPHATE'>TPW</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pdhA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Bacillus stearothermophilus]), pdhB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Bacillus stearothermophilus]), pdhC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Bacillus stearothermophilus])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dva OCA], [https://pdbe.org/3dva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dva RCSB], [https://www.ebi.ac.uk/pdbsum/3dva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dva ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_dehydrogenase_(acetyl-transferring) Pyruvate dehydrogenase (acetyl-transferring)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.4.1 1.2.4.1] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dva OCA], [http://pdbe.org/3dva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dva RCSB], [http://www.ebi.ac.uk/pdbsum/3dva PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dva ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/ODP2_GEOSE ODP2_GEOSE]] The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). [[http://www.uniprot.org/uniprot/ODPB_GEOSE ODPB_GEOSE]] The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
+
[https://www.uniprot.org/uniprot/ODPB_GEOSE ODPB_GEOSE] The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 33: Line 31:
==See Also==
==See Also==
-
*[[Dihydrolipoamide acetyltransferase|Dihydrolipoamide acetyltransferase]]
+
*[[Dihydrolipoamide acetyltransferase 3D structures|Dihydrolipoamide acetyltransferase 3D structures]]
-
*[[Pyruvate dehydrogenase|Pyruvate dehydrogenase]]
+
*[[Pyruvate dehydrogenase 3D structures|Pyruvate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Bacillus stearothermophilus]]
+
[[Category: Geobacillus stearothermophilus]]
-
[[Category: Frank, R A.W]]
+
[[Category: Large Structures]]
-
[[Category: Leeper, F J]]
+
[[Category: Frank RAW]]
-
[[Category: Luisi, B F]]
+
[[Category: Leeper FJ]]
-
[[Category: Pei, X Y]]
+
[[Category: Luisi BF]]
-
[[Category: Titman, C M]]
+
[[Category: Pei XY]]
-
[[Category: Acetyl transferase]]
+
[[Category: Titman CM]]
-
[[Category: Acyltransferase]]
+
-
[[Category: Dehydrogenase]]
+
-
[[Category: Dihydrolipoyl]]
+
-
[[Category: Glycolysis]]
+
-
[[Category: Multienzyme complex]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Oxidoreductase-transferase complex]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Pyruvate]]
+
-
[[Category: Thiamine pyrophosphate]]
+
-
[[Category: Transferase]]
+

Current revision

Snapshots of catalysis in the E1 subunit of the pyruvate dehydrogenase multi-enzyme complex

PDB ID 3dva

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3dva"
Personal tools