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3dxk
From Proteopedia
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==Structure of Bos Taurus Arp2/3 Complex with Bound Inhibitor CK0944636== | ==Structure of Bos Taurus Arp2/3 Complex with Bound Inhibitor CK0944636== | ||
| - | <StructureSection load='3dxk' size='340' side='right' caption='[[3dxk]], [[Resolution|resolution]] 2.70Å' scene=''> | + | <StructureSection load='3dxk' size='340' side='right'caption='[[3dxk]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3dxk]] is a 7 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3dxk]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DXK FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N23:N-[2-(2-METHYL-1H-INDOL-3-YL)ETHYL]THIOPHENE-2-CARBOXAMIDE'>N23</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dxk OCA], [https://pdbe.org/3dxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dxk RCSB], [https://www.ebi.ac.uk/pdbsum/3dxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dxk ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ARP3_BOVIN ARP3_BOVIN] Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/3dxk_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/3dxk_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dxk ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3dxk" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
| - | [[Category: Hartman | + | [[Category: Large Structures]] |
| - | [[Category: Jia | + | [[Category: Hartman J]] |
| - | [[Category: Nolen | + | [[Category: Jia Z]] |
| - | [[Category: Pierce | + | [[Category: Nolen BJ]] |
| - | [[Category: Pollard | + | [[Category: Pierce DW]] |
| - | [[Category: Russell | + | [[Category: Pollard TD]] |
| - | [[Category: Sakowicz | + | [[Category: Russell A]] |
| - | [[Category: Tomasevic | + | [[Category: Sakowicz R]] |
| - | + | [[Category: Tomasevic N]] | |
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Current revision
Structure of Bos Taurus Arp2/3 Complex with Bound Inhibitor CK0944636
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Categories: Bos taurus | Large Structures | Hartman J | Jia Z | Nolen BJ | Pierce DW | Pollard TD | Russell A | Sakowicz R | Tomasevic N
