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3e1k

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==Crystal structure of Kluyveromyces lactis Gal80p in complex with the acidic activation domain of Gal4p==
==Crystal structure of Kluyveromyces lactis Gal80p in complex with the acidic activation domain of Gal4p==
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<StructureSection load='3e1k' size='340' side='right' caption='[[3e1k]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='3e1k' size='340' side='right'caption='[[3e1k]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3e1k]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_sphaerica Candida sphaerica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E1K FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3e1k]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis] and [https://en.wikipedia.org/wiki/Kluyveromyces_lactis_NRRL_Y-1140 Kluyveromyces lactis NRRL Y-1140]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E1K FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GAL80 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28985 Candida sphaerica])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e1k OCA], [http://pdbe.org/3e1k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3e1k RCSB], [http://www.ebi.ac.uk/pdbsum/3e1k PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e1k OCA], [https://pdbe.org/3e1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e1k RCSB], [https://www.ebi.ac.uk/pdbsum/3e1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e1k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GAL80_KLULA GAL80_KLULA]] This protein is a negative regulator for the gene expression of the lactose/galactose metabolic genes. It seems to block activation by the transcriptional activator LAC9 in the absence of an inducing sugar. [[http://www.uniprot.org/uniprot/LAC9_KLULA LAC9_KLULA]] Positive regulatory protein, that controls induction of the lactose-galactose regulation of Kluyveromyces lactis.
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[https://www.uniprot.org/uniprot/GAL80_KLULA GAL80_KLULA] This protein is a negative regulator for the gene expression of the lactose/galactose metabolic genes. It seems to block activation by the transcriptional activator LAC9 in the absence of an inducing sugar.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/3e1k_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/3e1k_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Candida sphaerica]]
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[[Category: Kluyveromyces lactis]]
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[[Category: Holden, H M]]
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[[Category: Kluyveromyces lactis NRRL Y-1140]]
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[[Category: Thoden, J B]]
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[[Category: Large Structures]]
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[[Category: Activator]]
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[[Category: Holden HM]]
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[[Category: Carbohydrate metabolism]]
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[[Category: Thoden JB]]
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[[Category: Dna-binding]]
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[[Category: Galactose metabolism]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Repressor]]
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[[Category: Trans-activation]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transctiption]]
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Current revision

Crystal structure of Kluyveromyces lactis Gal80p in complex with the acidic activation domain of Gal4p

PDB ID 3e1k

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