3e5h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:58, 30 August 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3e5h.png|left|200px]]
 
-
<!--
+
==Crystal Structure of Rab28 GTPase in the Active (GppNHp-bound) Form==
-
The line below this paragraph, containing "STRUCTURE_3e5h", creates the "Structure Box" on the page.
+
<StructureSection load='3e5h' size='340' side='right'caption='[[3e5h]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3e5h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2hy4 2hy4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E5H FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.499&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
{{STRUCTURE_3e5h| PDB=3e5h | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e5h OCA], [https://pdbe.org/3e5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e5h RCSB], [https://www.ebi.ac.uk/pdbsum/3e5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e5h ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/RAB28_HUMAN RAB28_HUMAN] Cone rod dystrophy. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23746546</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RAB28_HUMAN RAB28_HUMAN]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/3e5h_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e5h ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Rab GTPases are essential regulators of membrane trafficking. We report crystal structures of Rab28 in the active (GppNHp-bound) and inactive (GDP-3'P-bound) forms at 1.5 and 1.1A resolution. Rab28 is a distant member of the Rab family. While the overall fold of Rab28 resembles that of other Rab GTPases, it undergoes a larger nucleotide-dependent conformational change than other members of this family. Added flexibility resulting from a double-glycine motif at the beginning of switch 2 might partially account for this observation. The double-glycine motif, which is conserved in the Arf family, only occurs in Rab28 and Rab7B of the Rab family, and may have a profound effect on their catalytic activities.
-
===Crystal Structure of Rab28 GTPase in the Active (GppNHp-bound) Form===
+
Large nucleotide-dependent conformational change in Rab28.,Lee SH, Baek K, Dominguez R FEBS Lett. 2008 Dec 10;582(29):4107-11. Epub 2008 Nov 19. PMID:19026641<ref>PMID:19026641</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3e5h" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_19026641}}, adds the Publication Abstract to the page
+
*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 19026641 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_19026641}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
3E5H is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2hy4 2hy4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E5H OCA].
+
-
 
+
-
==Reference==
+
-
Large nucleotide-dependent conformational change in Rab28., Lee SH, Baek K, Dominguez R, FEBS Lett. 2008 Dec 10;582(29):4107-11. Epub 2008 Nov 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19026641 19026641]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Baek, K.]]
+
[[Category: Large Structures]]
-
[[Category: Dominguez, R.]]
+
[[Category: Baek K]]
-
[[Category: Lee, S H.]]
+
[[Category: Dominguez R]]
-
[[Category: Li, Y.]]
+
[[Category: Lee SH]]
-
[[Category: Alternative splicing]]
+
[[Category: Li Y]]
-
[[Category: Cell membrane]]
+
-
[[Category: Gtp-binding]]
+
-
[[Category: Lipoprotein]]
+
-
[[Category: Membrane]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Prenylation]]
+
-
[[Category: Rab gtpase]]
+
-
[[Category: Signaling protein]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 24 11:12:27 2008''
+

Current revision

Crystal Structure of Rab28 GTPase in the Active (GppNHp-bound) Form

PDB ID 3e5h

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3e5h"
Personal tools