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3e9v
From Proteopedia
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| - | [[Image:3e9v.png|left|200px]] | ||
| - | + | ==Crystal structure of human B-cell Translocation Gene 2 (BTG2)== | |
| - | + | <StructureSection load='3e9v' size='340' side='right'caption='[[3e9v]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3e9v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E9V FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |
| - | == | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | [[3e9v]] is a 1 chain structure with sequence from [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e9v OCA], [https://pdbe.org/3e9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e9v RCSB], [https://www.ebi.ac.uk/pdbsum/3e9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e9v ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3e9v TOPSAN]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BTG2_HUMAN BTG2_HUMAN] Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Anti-proliferative protein. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.<ref>PMID:12771185</ref> <ref>PMID:15788397</ref> <ref>PMID:18773938</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e9/3e9v_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e9v ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Atwell | + | [[Category: Large Structures]] |
| - | [[Category: Burley | + | [[Category: Atwell S]] |
| - | [[Category: Freeman | + | [[Category: Burley SK]] |
| - | [[Category: Hu | + | [[Category: Freeman J]] |
| - | [[Category: Maletic | + | [[Category: Hu S]] |
| - | + | [[Category: Maletic M]] | |
| - | [[Category: Romero | + | [[Category: Romero R]] |
| - | [[Category: Sampathkumar | + | [[Category: Sampathkumar P]] |
| - | [[Category: Sauder | + | [[Category: Sauder JM]] |
| - | [[Category: Tarun | + | [[Category: Tarun G]] |
| - | [[Category: Wasserman | + | [[Category: Wasserman S]] |
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Current revision
Crystal structure of human B-cell Translocation Gene 2 (BTG2)
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Categories: Homo sapiens | Large Structures | Atwell S | Burley SK | Freeman J | Hu S | Maletic M | Romero R | Sampathkumar P | Sauder JM | Tarun G | Wasserman S
