3eb3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:00, 30 August 2023) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3eb3.jpg|left|200px]]
 
-
<!--
+
==Voltage-dependent K+ channel beta subunit (W121A) in complex with cortisone==
-
The line below this paragraph, containing "STRUCTURE_3eb3", creates the "Structure Box" on the page.
+
<StructureSection load='3eb3' size='340' side='right'caption='[[3eb3]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3eb3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EB3 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PDN:17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE'>PDN</scene></td></tr>
-
{{STRUCTURE_3eb3| PDB=3eb3 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eb3 OCA], [https://pdbe.org/3eb3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eb3 RCSB], [https://www.ebi.ac.uk/pdbsum/3eb3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eb3 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/KCAB2_RAT KCAB2_RAT] Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/3eb3_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eb3 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The Shaker family voltage-dependent potassium channels (Kv1) are expressed in a wide variety of cells and are essential for cellular excitability. In humans, loss-of-function mutations of Kv1 channels lead to hyperexcitability and are directly linked to episodic ataxia and atrial fibrillation. All Kv1 channels assemble with beta subunits (Kv betas), and certain Kv betas, for example Kv beta 1, have an N-terminal segment that closes the channel by the N-type inactivation mechanism. In principle, dissociation of Kv beta 1, although never reported, should eliminate inactivation and thus potentiate Kv1 current. We found that cortisone increases rat Kv1 channel activity by binding to Kv beta 1. A crystal structure of the Kv beta-cortisone complex was solved to 1.82-A resolution and revealed novel cortisone binding sites. Further studies demonstrated that cortisone promotes dissociation of Kv beta. The new mode of channel modulation may be explored by native or synthetic ligands to fine-tune cellular excitability.
-
===Voltage-dependent K+ channel beta subunit (W121A) in complex with cortisone===
+
Cortisone dissociates the Shaker family K+ channels from their beta subunits.,Pan Y, Weng J, Kabaleeswaran V, Li H, Cao Y, Bhosle RC, Zhou M Nat Chem Biol. 2008 Nov;4(11):708-14. Epub 2008 Sep 21. PMID:18806782<ref>PMID:18806782</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3eb3" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_10399921}}, adds the Publication Abstract to the page
+
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 10399921 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_10399921}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
3EB3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EB3 OCA].
+
-
 
+
-
==Reference==
+
-
Structure of a voltage-dependent K+ channel beta subunit., Gulbis JM, Mann S, MacKinnon R, Cell. 1999 Jun 25;97(7):943-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10399921 10399921]
+
-
 
+
-
Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels., Gulbis JM, Zhou M, Mann S, MacKinnon R, Science. 2000 Jul 7;289(5476):123-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10884227 10884227]
+
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: Single protein]]
+
[[Category: Bhosle RC]]
-
[[Category: Bhosle, R C.]]
+
[[Category: Cao Y]]
-
[[Category: Cao, Y.]]
+
[[Category: Kabaleeswaran V]]
-
[[Category: Kabaleeswaran, V.]]
+
[[Category: Li H]]
-
[[Category: Li, H.]]
+
[[Category: Pan Y]]
-
[[Category: Pan, Y.]]
+
[[Category: Weng J]]
-
[[Category: Weng, J.]]
+
[[Category: Zhou M]]
-
[[Category: Zhou, M.]]
+
-
[[Category: Cortisone]]
+
-
[[Category: Cytoplasm]]
+
-
[[Category: Interface]]
+
-
[[Category: Ion transport]]
+
-
[[Category: Ionic channel]]
+
-
[[Category: Kvbeta]]
+
-
[[Category: Nadp]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Potassium]]
+
-
[[Category: Potassium transport]]
+
-
[[Category: Transport]]
+
-
[[Category: Transport protein]]
+
-
[[Category: Voltage-gated channel]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 24 10:47:49 2008''
+

Current revision

Voltage-dependent K+ channel beta subunit (W121A) in complex with cortisone

PDB ID 3eb3

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3eb3"
Personal tools