3eb9

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[[Image:3eb9.png|left|200px]]
 
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==Crystal structure of 6-phosphogluconolactonase from trypanosoma brucei complexed with citrate==
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The line below this paragraph, containing "STRUCTURE_3eb9", creates the "Structure Box" on the page.
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<StructureSection load='3eb9' size='340' side='right'caption='[[3eb9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3eb9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EB9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3eb9| PDB=3eb9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eb9 OCA], [https://pdbe.org/3eb9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eb9 RCSB], [https://www.ebi.ac.uk/pdbsum/3eb9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eb9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9GRG6_9TRYP Q9GRG6_9TRYP]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/3eb9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eb9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Trypanosoma brucei is the causative agent of African sleeping sickness. Current work for the development of new drugs against this pathology includes evaluation of enzymes of the pentose phosphate pathway (PPP), which first requires a clear understanding of their function and mechanism of action. In this context, we focused on T. brucei 6-phosphogluconolactonase (Tb6PGL), which converts delta-6-phosphogluconolactone into 6-phosphogluconic acid in the second step of the PPP. We have determined the crystal structure of Tb6PGL in complex with two ligands, 6-phosphogluconic acid and citrate, at 2.2 A and 2.0 A resolution, respectively. We have performed molecular dynamics (MD) simulations on Tb6PGL in its empty form and in complex with delta-6-phosphogluconolactone, its natural ligand. Analysis of the structural data and MD simulations allowed us to propose a detailed enzymatic mechanism for 6PGL enzymes.
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===Crystal structure of 6-phosphogluconolactonase from trypanosoma brucei complexed with citrate===
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Insights into the enzymatic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei using structural data and molecular dynamics simulation.,Duclert-Savatier N, Poggi L, Miclet E, Lopes P, Ouazzani J, Chevalier N, Nilges M, Delarue M, Stoven V J Mol Biol. 2009 May 22;388(5):1009-21. Epub 2009 Apr 1. PMID:19345229<ref>PMID:19345229</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3eb9" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19345229 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19345229}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3eb9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EB9 OCA].
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==Reference==
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<ref group="xtra">PMID:019345229</ref><references group="xtra"/>
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[[Category: Gluconolactonase]]
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[[Category: Trypanosoma brucei]]
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[[Category: Delarue, M.]]
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[[Category: Duclert-Savatier, N.]]
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[[Category: Poggi, L.]]
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[[Category: Stoven, V.]]
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[[Category: 6-phosphogluconolactonase]]
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[[Category: Catalytic mechanism]]
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[[Category: Hydrolase]]
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[[Category: Pentose phosphate pathway]]
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[[Category: Trypanosoma brucei]]
[[Category: Trypanosoma brucei]]
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[[Category: Zinc binding site]]
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[[Category: Delarue M]]
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[[Category: Duclert-Savatier N]]
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[[Category: Poggi L]]
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[[Category: Stoven V]]

Current revision

Crystal structure of 6-phosphogluconolactonase from trypanosoma brucei complexed with citrate

PDB ID 3eb9

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