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4oog

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==Crystal structure of yeast RNase III (Rnt1p) complexed with the product of dsRNA processing==
==Crystal structure of yeast RNase III (Rnt1p) complexed with the product of dsRNA processing==
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<StructureSection load='4oog' size='340' side='right' caption='[[4oog]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='4oog' size='340' side='right'caption='[[4oog]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4oog]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OOG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OOG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4oog]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OOG FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2nug|2nug]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RNT1, YM9408.01C, YM9959.21, YMR239C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oog OCA], [https://pdbe.org/4oog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oog RCSB], [https://www.ebi.ac.uk/pdbsum/4oog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oog ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oog OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oog RCSB], [http://www.ebi.ac.uk/pdbsum/4oog PDBsum]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/RNT1_YEAST RNT1_YEAST] DsRNA-specific nuclease that cleaves eukaryotic pre-ribosomal RNA at the U3 snoRNP-dependent A0 site in the 5'-external transcribed spacer (ETS) and in the 3'-ETS. In vitro, cleaves synthetic 5'-ETS RNA A0 site in the absence of snoRNA or other factors. Has an essential growth function in addition to pre-rRNA processing.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structure of a Eukaryotic RNase III Postcleavage Complex Reveals a Double-Ruler Mechanism for Substrate Selection.,Liang YH, Lavoie M, Comeau MA, Abou Elela S, Ji X Mol Cell. 2014 Apr 2. pii: S1097-2765(14)00211-1. doi:, 10.1016/j.molcel.2014.03.006. PMID:24703949<ref>PMID:24703949</ref>
Structure of a Eukaryotic RNase III Postcleavage Complex Reveals a Double-Ruler Mechanism for Substrate Selection.,Liang YH, Lavoie M, Comeau MA, Abou Elela S, Ji X Mol Cell. 2014 Apr 2. pii: S1097-2765(14)00211-1. doi:, 10.1016/j.molcel.2014.03.006. PMID:24703949<ref>PMID:24703949</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4oog" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baker's yeast]]
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[[Category: Large Structures]]
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[[Category: Ribonuclease III]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Ji, X.]]
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[[Category: Ji X]]
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[[Category: Liang, Y H.]]
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[[Category: Liang Y-H]]
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[[Category: Double-stranded rna]]
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[[Category: Double-stranded rna-binding domain]]
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[[Category: Dsrna-specific rnase]]
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[[Category: Endoribonuclease]]
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[[Category: Hydrolase-rna complex]]
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[[Category: Ribonuclease iii domain]]
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[[Category: Rnase:rna complex]]
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Current revision

Crystal structure of yeast RNase III (Rnt1p) complexed with the product of dsRNA processing

PDB ID 4oog

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