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2jw1

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Current revision (13:35, 30 August 2023) (edit) (undo)
 
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==Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy==
==Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy==
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<StructureSection load='2jw1' size='340' side='right'caption='[[2jw1]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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<StructureSection load='2jw1' size='340' side='right'caption='[[2jw1]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jw1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JW1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jw1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JW1 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mxiM ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 "Shigella paradysenteriae" Weldin 1927])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jw1 OCA], [https://pdbe.org/2jw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jw1 RCSB], [https://www.ebi.ac.uk/pdbsum/2jw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jw1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jw1 OCA], [https://pdbe.org/2jw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jw1 RCSB], [https://www.ebi.ac.uk/pdbsum/2jw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jw1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MXIM_SHIFL MXIM_SHIFL]] Involved in the secretion of the Ipa antigens. [[https://www.uniprot.org/uniprot/MXID_SHIFL MXID_SHIFL]] Necessary for the secretion of IPA invasins.
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[https://www.uniprot.org/uniprot/SCTG_SHIFL SCTG_SHIFL] Involved in the synthesis of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:10085046, PubMed:11717255). Pilot protein that is required for the proper localization of the secretin MxiD/SctC in the outer membrane (PubMed:11717255). Also influences both MxiD/SctC multimerization and stability (PubMed:11717255). Required for both Ipa translocation and tissue culture cell invasion (PubMed:10085046). Binds lipids (PubMed:15775974).<ref>PMID:10085046</ref> <ref>PMID:11717255</ref> <ref>PMID:15775974</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Shigella paradysenteriae weldin 1927]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Creagh, L]]
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[[Category: Shigella flexneri]]
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[[Category: Jung, Y M.T]]
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[[Category: Synthetic construct]]
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[[Category: Lario, P I]]
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[[Category: Creagh L]]
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[[Category: Maurelli, A T]]
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[[Category: Jung YMT]]
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[[Category: McIntosh, L P]]
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[[Category: Lario PI]]
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[[Category: Okon, M S]]
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[[Category: Maurelli AT]]
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[[Category: Strynadka, N C.J]]
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[[Category: McIntosh LP]]
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[[Category: Lipoprotein]]
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[[Category: Okon MS]]
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[[Category: Membrane]]
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[[Category: Strynadka NCJ]]
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[[Category: Membrane protein]]
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[[Category: Outer membrane]]
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[[Category: Palmitate]]
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[[Category: Plasmid]]
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[[Category: Protein transport]]
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[[Category: Protein-protein interaction]]
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[[Category: Transport]]
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[[Category: Virulence]]
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Current revision

Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy

PDB ID 2jw1

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