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5ig6

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==Ultra-high resolution crystal structure of second bromodomain of BRD2 in complex with inhibitor 6B3==
==Ultra-high resolution crystal structure of second bromodomain of BRD2 in complex with inhibitor 6B3==
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<StructureSection load='5ig6' size='340' side='right' caption='[[5ig6]], [[Resolution|resolution]] 0.91&Aring;' scene=''>
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<StructureSection load='5ig6' size='340' side='right'caption='[[5ig6]], [[Resolution|resolution]] 0.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ig6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IG6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ig6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IG6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6B3:2-[(6-OXO-5,6-DIHYDROPHENANTHRIDIN-3-YL)CARBAMOYL][1,1-BIPHENYL]-2-CARBOXYLIC+ACID'>6B3</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.91&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ibn|5ibn]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6B3:2-[(6-OXO-5,6-DIHYDROPHENANTHRIDIN-3-YL)CARBAMOYL][1,1-BIPHENYL]-2-CARBOXYLIC+ACID'>6B3</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ig6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ig6 OCA], [http://pdbe.org/5ig6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ig6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ig6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ig6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ig6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ig6 OCA], [https://pdbe.org/5ig6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ig6 RCSB], [https://www.ebi.ac.uk/pdbsum/5ig6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ig6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
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[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ig6" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ig6" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Padmanabhan, B]]
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[[Category: Homo sapiens]]
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[[Category: Tripathi, S K]]
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[[Category: Large Structures]]
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[[Category: Bet-family]]
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[[Category: Padmanabhan B]]
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[[Category: Inhibitor]]
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[[Category: Tripathi SK]]
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[[Category: Transcription]]
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Current revision

Ultra-high resolution crystal structure of second bromodomain of BRD2 in complex with inhibitor 6B3

PDB ID 5ig6

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