1mlv

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[[Image:1mlv.gif|left|200px]]
[[Image:1mlv.gif|left|200px]]
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{{Structure
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|PDB= 1mlv |SIZE=350|CAPTION= <scene name='initialview01'>1mlv</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1mlv", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/[Ribulose-bisphosphate_carboxylase]-lysine_N-methyltransferase [Ribulose-bisphosphate carboxylase]-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.127 2.1.1.127] </span>
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1mlv| PDB=1mlv | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mlv OCA], [http://www.ebi.ac.uk/pdbsum/1mlv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mlv RCSB]</span>
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'''Structure and Catalytic Mechanism of a SET Domain Protein Methyltransferase'''
'''Structure and Catalytic Mechanism of a SET Domain Protein Methyltransferase'''
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[[Category: Pisum sativum]]
[[Category: Pisum sativum]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: [Ribulose-bisphosphate carboxylase]-lysine N-methyltransferase]]
 
[[Category: Beach, B M.]]
[[Category: Beach, B M.]]
[[Category: Dirk, L M.A.]]
[[Category: Dirk, L M.A.]]
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[[Category: Hurley, J H.]]
[[Category: Hurley, J H.]]
[[Category: Trievel, R C.]]
[[Category: Trievel, R C.]]
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[[Category: lysine n-methylation]]
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[[Category: Lysine n-methylation]]
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[[Category: photosynthesis]]
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[[Category: Photosynthesis]]
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[[Category: post-translational modification]]
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[[Category: Post-translational modification]]
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[[Category: set domain]]
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[[Category: Set domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:23:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:17:52 2008''
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Revision as of 22:23, 2 May 2008

Image:1mlv.gif

Template:STRUCTURE 1mlv

Structure and Catalytic Mechanism of a SET Domain Protein Methyltransferase


Overview

Protein lysine methylation by SET domain enzymes regulates chromatin structure, gene silencing, transcriptional activation, plant metabolism, and other processes. The 2.6 A resolution structure of Rubisco large subunit methyltransferase in a pseudo-bisubstrate complex with S-adenosylhomocysteine and a HEPES ion reveals an all-beta architecture for the SET domain embedded within a larger alpha-helical enzyme fold. Conserved regions of the SET domain bind S-adenosylmethionine and substrate lysine at two sites connected by a pore. We propose that methyl transfer is catalyzed by a conserved Tyr at a narrow pore connecting the sites. The cofactor enters by a "back door" on the opposite side of the enzyme from substrate, promoting highly specific protein recognition and allowing addition of multiple methyl groups.

About this Structure

1MLV is a Single protein structure of sequence from Pisum sativum. Full crystallographic information is available from OCA.

Reference

Structure and catalytic mechanism of a SET domain protein methyltransferase., Trievel RC, Beach BM, Dirk LM, Houtz RL, Hurley JH, Cell. 2002 Oct 4;111(1):91-103. PMID:12372303 Page seeded by OCA on Sat May 3 01:23:49 2008

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