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5ikw

From Proteopedia

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Current revision (13:59, 30 August 2023) (edit) (undo)
 
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<StructureSection load='5ikw' size='340' side='right'caption='[[5ikw]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
<StructureSection load='5ikw' size='340' side='right'caption='[[5ikw]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ikw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IKW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IKW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ikw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IKW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6BU:N-(6-{3-[(CYCLOPROPYLSULFONYL)AMINO]PHENYL}-1H-INDAZOL-3-YL)CYCLOPROPANECARBOXAMIDE'>6BU</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BMP2K, BIKE, HRIHFB2017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6BU:N-(6-{3-[(CYCLOPROPYLSULFONYL)AMINO]PHENYL}-1H-INDAZOL-3-YL)CYCLOPROPANECARBOXAMIDE'>6BU</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ikw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ikw OCA], [https://pdbe.org/5ikw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ikw RCSB], [https://www.ebi.ac.uk/pdbsum/5ikw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ikw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ikw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ikw OCA], [http://pdbe.org/5ikw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ikw RCSB], [http://www.ebi.ac.uk/pdbsum/5ikw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ikw ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BMP2K_HUMAN BMP2K_HUMAN]] May be involved in osteoblast differentiation.
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[https://www.uniprot.org/uniprot/BMP2K_HUMAN BMP2K_HUMAN] May be involved in osteoblast differentiation.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arruda P]]
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[[Category: Arruda, P]]
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[[Category: Axtman A]]
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[[Category: Axtman, A]]
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[[Category: Bountra C]]
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[[Category: Bountra, C]]
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[[Category: Counago RM]]
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[[Category: Counago, R M]]
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[[Category: Drewry D]]
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[[Category: Drewry, D]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M]]
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[[Category: Elkins JM]]
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[[Category: Elkins, J M]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O]]
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[[Category: Krojer T]]
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[[Category: Krojer, T]]
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[[Category: Savitsky P]]
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[[Category: Structural genomic]]
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[[Category: Sorrell FJ]]
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[[Category: Savitsky, P]]
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[[Category: Wells C]]
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[[Category: Sorrell, F J]]
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[[Category: Willson TM]]
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[[Category: Wells, C]]
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[[Category: Zhang C]]
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[[Category: Willson, T M]]
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[[Category: Zuercher W]]
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[[Category: Zhang, C]]
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[[Category: Zuercher, W]]
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[[Category: Protein kinase domain]]
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[[Category: Sgc]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor

PDB ID 5ikw

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