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5imt

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==Toxin receptor complex==
==Toxin receptor complex==
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<StructureSection load='5imt' size='340' side='right' caption='[[5imt]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='5imt' size='340' side='right'caption='[[5imt]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5imt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IMT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5imt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_intermedius Streptococcus intermedius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IMT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7001&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5imt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5imt OCA], [http://pdbe.org/5imt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5imt RCSB], [http://www.ebi.ac.uk/pdbsum/5imt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5imt ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5imt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5imt OCA], [https://pdbe.org/5imt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5imt RCSB], [https://www.ebi.ac.uk/pdbsum/5imt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5imt ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:[http://omim.org/entry/612300 612300]].<ref>PMID:1382994</ref>
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
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[https://www.uniprot.org/uniprot/Q9LCB8_STRIT Q9LCB8_STRIT]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5imt" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5imt" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[CD59|CD59]]
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*[[Cytolysin 3D structures|Cytolysin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Feil, S C]]
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[[Category: Homo sapiens]]
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[[Category: Lawrence, S L]]
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[[Category: Large Structures]]
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[[Category: Morton, C J]]
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[[Category: Streptococcus intermedius]]
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[[Category: Parker, M W]]
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[[Category: Feil SC]]
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[[Category: Cytolysin]]
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[[Category: Lawrence SL]]
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[[Category: Toxin]]
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[[Category: Morton CJ]]
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[[Category: Parker MW]]

Current revision

Toxin receptor complex

PDB ID 5imt

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