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5irs

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==crystal structure of the proteasomal Rpn13 PRU-domain==
==crystal structure of the proteasomal Rpn13 PRU-domain==
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<StructureSection load='5irs' size='340' side='right' caption='[[5irs]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='5irs' size='340' side='right'caption='[[5irs]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5irs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IRS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5irs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IRS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.796&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5irs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5irs OCA], [http://pdbe.org/5irs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5irs RCSB], [http://www.ebi.ac.uk/pdbsum/5irs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5irs ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5irs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5irs OCA], [https://pdbe.org/5irs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5irs RCSB], [https://www.ebi.ac.uk/pdbsum/5irs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5irs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ADRM1_HUMAN ADRM1_HUMAN]] Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity.<ref>PMID:16990800</ref> <ref>PMID:17139257</ref> <ref>PMID:16815440</ref> <ref>PMID:16906146</ref> <ref>PMID:18497817</ref>
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[https://www.uniprot.org/uniprot/ADRM1_HUMAN ADRM1_HUMAN] Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity.<ref>PMID:16990800</ref> <ref>PMID:17139257</ref> <ref>PMID:16815440</ref> <ref>PMID:16906146</ref> <ref>PMID:18497817</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aihara, H]]
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[[Category: Homo sapiens]]
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[[Category: Chen, X]]
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[[Category: Large Structures]]
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[[Category: Shi, K]]
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[[Category: Aihara H]]
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[[Category: Walters, K]]
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[[Category: Chen X]]
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[[Category: Protein binding]]
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[[Category: Shi K]]
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[[Category: Ubiquitin]]
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[[Category: Walters K]]

Current revision

crystal structure of the proteasomal Rpn13 PRU-domain

PDB ID 5irs

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