Plexin

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{{STRUCTURE_3ig3| PDB=3ig3 | SIZE=400| SCENE= |right|CAPTION=Mouse plexin-A3 intracellular domain complex with glycerol, [[3ig3]] }}
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<StructureSection load='' size='350' side='right' caption='Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry [[3nvn]])' scene='46/466532/Cv/1' pspeed='8'>
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'''Plexin''' (PLX) is the receptor for semaphorin<ref>PMID:20877282</ref>.
'''Plexin''' (PLX) is the receptor for semaphorin<ref>PMID:20877282</ref>.
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==3D structures of plexin==
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*'''Plexin A''' controls axon guidance<ref>PMID:9875845</ref>.
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*'''Plexin B''' regulates Rho GTPase<ref>PMID:12183458</ref>.
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*'''Plexin C''' is the receptor for GPI-anchored semaphorin Sema7A<ref>PMID:10520995</ref>.
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{{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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== Structural highlights ==
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Plexin A
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*<scene name='46/466532/Cv/4'>Plexin C1 interactions with semaphoric SEMA7A</scene>. Water molecules are shown as red spheres.
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*<scene name='46/466532/Cv/5'>Ca coordination site</scene>.
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**[[3al8]], [[3oky]] – mPLX-A2 + semaphorin-6A – mouse<br />
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==3D structures of plexin==
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**[[4gza]] - mPLX-A2 + semaphorin-3A + neuropilin-1<br />
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[[Plexin 3D structures]]
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**[[3al9]], [[3okt]] – mPLX-A2 extracellular domain<br />
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</StructureSection>
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**[[3ig3]] - mPLX-A3 intracellular domain<br />
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**[[3ryt]] - mPLX-A1 intracellular domain + Ras-related C3 botulinum toxin substrate<br />
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**[[3q3j]] - hPLX-A2 binding domain + Rho-related GTP-binding protein Rho6 – human<br />
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**[[4e74]] - hPLX-A4 Rho GTPase-binding domain
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*Plexin B
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**[[2r2o]] – hPLX-B1 effector domain
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**[[2rex]] - hPLX-B1 effector domain + Rho-related GTP-binding protein Rho6
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**[[2jph]] - hPLX-B1 Rho GTPase-binding domain – NMR<br />
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**[[4e71]] - hPLX-B2 Rho GTPase-binding domain<br />
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**[[3ol2]] - hPLX-B1 + semaphorin 4D
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**[[3sua]], [[3su8]] – hPLX-B1 + RAS-related C3 botulinum toxin substrate
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**[[3hm6]] - hPLX-B1 cytoplasmic domain + peptide
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*Plexin C
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**[[3kuz]] - hPLX-C1 ubiquitin-like domain
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**[[3nvn]], [[3nvq]] – hPLX-C1 + semaphorin 7A
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*Plexin D
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**[[3h6n]] - hPLX-D1 ubiquitin-like domain
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry 3nvn)

Drag the structure with the mouse to rotate

References

  1. ↑ Janssen BJ, Robinson RA, Perez-Branguli F, Bell CH, Mitchell KJ, Siebold C, Jones EY. Structural basis of semaphorin-plexin signalling. Nature. 2010 Sep 26. PMID:20877282 doi:10.1038/nature09468
  2. ↑ Winberg ML, Noordermeer JN, Tamagnone L, Comoglio PM, Spriggs MK, Tessier-Lavigne M, Goodman CS. Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell. 1998 Dec 23;95(7):903-16. PMID:9875845
  3. ↑ Perrot V, Vazquez-Prado J, Gutkind JS. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. J Biol Chem. 2002 Nov 8;277(45):43115-20. Epub 2002 Aug 14. PMID:12183458 doi:http://dx.doi.org/10.1074/jbc.M206005200
  4. ↑ Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell. 1999 Oct 1;99(1):71-80. PMID:10520995

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