This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Plexin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:41, 3 September 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
<StructureSection load='3nvn' size='450' side='right' caption='Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry [[3nvn]])' scene='46/466532/Cv/1' pspeed='8'>
+
<StructureSection load='' size='350' side='right' caption='Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry [[3nvn]])' scene='46/466532/Cv/1' pspeed='8'>
'''Plexin''' (PLX) is the receptor for semaphorin<ref>PMID:20877282</ref>.
'''Plexin''' (PLX) is the receptor for semaphorin<ref>PMID:20877282</ref>.
*'''Plexin A''' controls axon guidance<ref>PMID:9875845</ref>.
*'''Plexin A''' controls axon guidance<ref>PMID:9875845</ref>.
*'''Plexin B''' regulates Rho GTPase<ref>PMID:12183458</ref>.
*'''Plexin B''' regulates Rho GTPase<ref>PMID:12183458</ref>.
 +
*'''Plexin C''' is the receptor for GPI-anchored semaphorin Sema7A<ref>PMID:10520995</ref>.
== Structural highlights ==
== Structural highlights ==
-
*<scene name='46/466532/Cv/2'>Plexin C1 interactions with semaphoric SEMA7A</scene>. Water molecules shown as red spheres.
+
*<scene name='46/466532/Cv/4'>Plexin C1 interactions with semaphoric SEMA7A</scene>. Water molecules are shown as red spheres.
-
*<scene name='46/466532/Cv/3'>Ca coordination site</scene>.
+
*<scene name='46/466532/Cv/5'>Ca coordination site</scene>.
 +
==3D structures of plexin==
 +
[[Plexin 3D structures]]
</StructureSection>
</StructureSection>
-
==3D structures of plexin==
 
- 
-
{{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
-
{{#tree:id=OrganizedByTopic|openlevels=0|
 
- 
-
*Plexin A
 
- 
-
**[[3al8]], [[3oky]] – mPLX-A2 + semaphorin-6A – mouse<br />
 
-
**[[4gza]] - mPLX-A2 + semaphorin-3A + neuropilin-1<br />
 
-
**[[3al9]], [[3okt]] – mPLX-A2 extracellular domain<br />
 
-
**[[3ig3]] - mPLX-A3 intracellular domain<br />
 
-
**[[3ryt]] - mPLX-A1 intracellular domain + Ras-related C3 botulinum toxin substrate<br />
 
-
**[[3q3j]] - hPLX-A2 binding domain + Rho-related GTP-binding protein Rho6 – human<br />
 
-
**[[4e74]] - hPLX-A4 Rho GTPase-binding domain
 
- 
-
*Plexin B
 
- 
-
**[[2r2o]] – hPLX-B1 effector domain
 
- 
-
**[[2rex]] - hPLX-B1 effector domain + Rho-related GTP-binding protein Rho6
 
- 
-
**[[2jph]] - hPLX-B1 Rho GTPase-binding domain – NMR<br />
 
-
**[[4e71]] - hPLX-B2 Rho GTPase-binding domain<br />
 
-
**[[3ol2]] - hPLX-B1 + semaphorin 4D
 
- 
-
**[[3sua]], [[3su8]] – hPLX-B1 + RAS-related C3 botulinum toxin substrate
 
- 
-
**[[3hm6]] - hPLX-B1 cytoplasmic domain + peptide
 
- 
-
*Plexin C
 
- 
-
**[[3kuz]] - hPLX-C1 ubiquitin-like domain
 
- 
-
**[[3nvn]], [[3nvq]] – hPLX-C1 + semaphorin 7A
 
- 
-
*Plexin D
 
-
**[[3h6n]] - hPLX-D1 ubiquitin-like domain
 
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry 3nvn)

Drag the structure with the mouse to rotate

References

  1. ↑ Janssen BJ, Robinson RA, Perez-Branguli F, Bell CH, Mitchell KJ, Siebold C, Jones EY. Structural basis of semaphorin-plexin signalling. Nature. 2010 Sep 26. PMID:20877282 doi:10.1038/nature09468
  2. ↑ Winberg ML, Noordermeer JN, Tamagnone L, Comoglio PM, Spriggs MK, Tessier-Lavigne M, Goodman CS. Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell. 1998 Dec 23;95(7):903-16. PMID:9875845
  3. ↑ Perrot V, Vazquez-Prado J, Gutkind JS. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. J Biol Chem. 2002 Nov 8;277(45):43115-20. Epub 2002 Aug 14. PMID:12183458 doi:http://dx.doi.org/10.1074/jbc.M206005200
  4. ↑ Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell. 1999 Oct 1;99(1):71-80. PMID:10520995

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Plexin"
Personal tools