Plexin
From Proteopedia
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| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' caption='Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry [[3nvn]])' scene='46/466532/Cv/1' pspeed='8'> |
'''Plexin''' (PLX) is the receptor for semaphorin<ref>PMID:20877282</ref>. | '''Plexin''' (PLX) is the receptor for semaphorin<ref>PMID:20877282</ref>. | ||
*'''Plexin A''' controls axon guidance<ref>PMID:9875845</ref>. | *'''Plexin A''' controls axon guidance<ref>PMID:9875845</ref>. | ||
*'''Plexin B''' regulates Rho GTPase<ref>PMID:12183458</ref>. | *'''Plexin B''' regulates Rho GTPase<ref>PMID:12183458</ref>. | ||
| + | *'''Plexin C''' is the receptor for GPI-anchored semaphorin Sema7A<ref>PMID:10520995</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
| - | *<scene name='46/466532/Cv/ | + | *<scene name='46/466532/Cv/4'>Plexin C1 interactions with semaphoric SEMA7A</scene>. Water molecules are shown as red spheres. |
| - | *<scene name='46/466532/Cv/ | + | *<scene name='46/466532/Cv/5'>Ca coordination site</scene>. |
| + | ==3D structures of plexin== | ||
| + | [[Plexin 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
| - | ==3D structures of plexin== | ||
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| - | {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Plexin A | ||
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| - | **[[3al8]], [[3oky]] – mPLX-A2 + semaphorin-6A – mouse<br /> | ||
| - | **[[4gza]] - mPLX-A2 + semaphorin-3A + neuropilin-1<br /> | ||
| - | **[[3al9]], [[3okt]] – mPLX-A2 extracellular domain<br /> | ||
| - | **[[3ig3]] - mPLX-A3 intracellular domain<br /> | ||
| - | **[[3ryt]] - mPLX-A1 intracellular domain + Ras-related C3 botulinum toxin substrate<br /> | ||
| - | **[[3q3j]] - hPLX-A2 binding domain + Rho-related GTP-binding protein Rho6 – human<br /> | ||
| - | **[[4e74]] - hPLX-A4 Rho GTPase-binding domain | ||
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| - | *Plexin B | ||
| - | |||
| - | **[[2r2o]] – hPLX-B1 effector domain | ||
| - | |||
| - | **[[2rex]] - hPLX-B1 effector domain + Rho-related GTP-binding protein Rho6 | ||
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| - | **[[2jph]] - hPLX-B1 Rho GTPase-binding domain – NMR<br /> | ||
| - | **[[4e71]] - hPLX-B2 Rho GTPase-binding domain<br /> | ||
| - | **[[3ol2]] - hPLX-B1 + semaphorin 4D | ||
| - | |||
| - | **[[3sua]], [[3su8]] – hPLX-B1 + RAS-related C3 botulinum toxin substrate | ||
| - | |||
| - | **[[3hm6]] - hPLX-B1 cytoplasmic domain + peptide | ||
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| - | *Plexin C | ||
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| - | **[[3kuz]] - hPLX-C1 ubiquitin-like domain | ||
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| - | **[[3nvn]], [[3nvq]] – hPLX-C1 + semaphorin 7A | ||
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| - | *Plexin D | ||
| - | **[[3h6n]] - hPLX-D1 ubiquitin-like domain | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Janssen BJ, Robinson RA, Perez-Branguli F, Bell CH, Mitchell KJ, Siebold C, Jones EY. Structural basis of semaphorin-plexin signalling. Nature. 2010 Sep 26. PMID:20877282 doi:10.1038/nature09468
- ↑ Winberg ML, Noordermeer JN, Tamagnone L, Comoglio PM, Spriggs MK, Tessier-Lavigne M, Goodman CS. Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell. 1998 Dec 23;95(7):903-16. PMID:9875845
- ↑ Perrot V, Vazquez-Prado J, Gutkind JS. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. J Biol Chem. 2002 Nov 8;277(45):43115-20. Epub 2002 Aug 14. PMID:12183458 doi:http://dx.doi.org/10.1074/jbc.M206005200
- ↑ Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell. 1999 Oct 1;99(1):71-80. PMID:10520995
