Poly(ADP-ribose) polymerase 3D structures
From Proteopedia
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**[[2n8a]] - hPARP-1 zinc fingers 1,2+ DNA – NMR<br /> | **[[2n8a]] - hPARP-1 zinc fingers 1,2+ DNA – NMR<br /> | ||
**[[2cr9]] - hPARP 1 WGR domain – NMR<br /> | **[[2cr9]] - hPARP 1 WGR domain – NMR<br /> | ||
| + | **[[7aaa]], [[7kk2]] – hPARP 1 catalytic domain<br /> | ||
**[[3l3l]], [[3l3m]], [[3gn7]], [[4l6s]] – hPARP 1 catalytic domain (mutant) + inhibitor<br /> | **[[3l3l]], [[3l3m]], [[3gn7]], [[4l6s]] – hPARP 1 catalytic domain (mutant) + inhibitor<br /> | ||
**[[2rcw]], [[4pjt]] - hPARP 1 α-helical and catalytic domain + inhibitor<br /> | **[[2rcw]], [[4pjt]] - hPARP 1 α-helical and catalytic domain + inhibitor<br /> | ||
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**[[3u9h]] – hPARP-1 catalytic domain + nicotinamide<br /> | **[[3u9h]] – hPARP-1 catalytic domain + nicotinamide<br /> | ||
**[[6bhv]] – hPARP 1 catalytic domain + NAD homolog<br /> | **[[6bhv]] – hPARP 1 catalytic domain + NAD homolog<br /> | ||
| - | **[[1uk0]], [[1uk1]], [[4gv7]], [[1wok]], [[4hhy]], [[4hhz]], [[2rd6]], [[4r5w]], [[4r6e]], [[4rv6]], [[4und]], [[4uxb]], [[4zzz]], [[5a00]], [[5ds3]], [[5ha9]], [[5xsu]], [[5xst]], [[5xsr]], [[6vkk]], [[6i8t]], [[6vko]], [[6vkq]], [[6xvw]] – hPARP-1 catalytic domain + inhibitor<br /> | + | **[[1uk0]], [[1uk1]], [[4gv7]], [[1wok]], [[4hhy]], [[4hhz]], [[2rd6]], [[4r5w]], [[4r6e]], [[4rv6]], [[4und]], [[4uxb]], [[4zzz]], [[5a00]], [[5ds3]], [[5ha9]], [[5xsu]], [[5xst]], [[5xsr]], [[6vkk]], [[6i8t]], [[6vko]], [[6vkq]], [[6xvw]], [[7aab]], [[7onr]], [[7ons]], [[7ont]] – hPARP-1 catalytic domain + inhibitor<br /> |
**[[3l3l]], [[3l3m]], [[3gn7]], [[4l6s]], [[5kpn]], [[5kpo]], [[5kpp]], [[5kpq]], [[5wrq]], [[5wry]], [[5wrz]], [[5ws0]], [[5ws1]], [[5wtc]], [[6ghk]] – hPARP 1 catalytic domain (mutant) + inhibitor<br /> | **[[3l3l]], [[3l3m]], [[3gn7]], [[4l6s]], [[5kpn]], [[5kpo]], [[5kpp]], [[5kpq]], [[5wrq]], [[5wry]], [[5wrz]], [[5ws0]], [[5ws1]], [[5wtc]], [[6ghk]] – hPARP 1 catalytic domain (mutant) + inhibitor<br /> | ||
| + | **[[7kk3]], [[7kk4]], [[7kk5]], [[7kk6]] – hPARP 1 catalytic domain + drug<br /> | ||
| + | **[[7aac]], [[7aad]], [[7cmw]] – hPARP 1 catalytic domain (mutant) + drug<br /> | ||
**[[6nrf]], [[6nrg]], [[6nrh]], [[6nri]], [[6nrj]], [[6ntu]] – hPARP 1 ART domain + inhibitor<br /> | **[[6nrf]], [[6nrg]], [[6nrh]], [[6nri]], [[6nrj]], [[6ntu]] – hPARP 1 ART domain + inhibitor<br /> | ||
**[[4xhu]] – hPARP 1 catalytic domain + protein homeless homolog<br /> | **[[4xhu]] – hPARP 1 catalytic domain + protein homeless homolog<br /> | ||
| - | **[[4opx]], [[4oqa]], [[4oqb]] – hPARP-1 zinc fingers 1,2,3, WGR and catalytic domain + DNA<br /> | + | **[[4opx]], [[4oqa]], [[4oqb]], [[7s68]], [[7s6h]], [[7s6m]], [[7s81]] – hPARP-1 zinc fingers 1,2,3, WGR and catalytic domain + DNA<br /> |
| + | **[[6m3i]], [[6nrf]], [[6nrg]], [[6nrh]], [[6nri]], [[6nrj]], [[6ntu]] – hPARP 1 ART domain + inhibitor<br /> | ||
| + | **[[7scy]], [[7scz]] - h PARP-1 BRCT domain in Nuc147 complex – Cryo EM<br /> | ||
**[[2le0]] - PARP-1 BRCT domain – rat - NMR<br /> | **[[2le0]] - PARP-1 BRCT domain – rat - NMR<br /> | ||
**[[6i8m]], [[6imt]] – cPARP-1 catalytic domain + inhibitor – chicken<br /> | **[[6i8m]], [[6imt]] – cPARP-1 catalytic domain + inhibitor – chicken<br /> | ||
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**[[6x0l]], [[6x0m]] - hPARP 2 + HPF1 + DNA – Cryo EM<br /> | **[[6x0l]], [[6x0m]] - hPARP 2 + HPF1 + DNA – Cryo EM<br /> | ||
| - | **[[6x0n]] - hPARP 2 + HPF1 + | + | **[[6usj]] - hPARP 2 + nucleosome – Cryo EM<br /> |
| - | **[[3kjd]], [[3kcz]], [[4tvj]], [[4zzx]], [[4zzy]], [[5dsy]] - hPARP 2 catalytic domain + inhibitor<br /> | + | **[[6x0n]] - hPARP 2 + HPF1 + nucleosome – Cryo EM<br /> |
| + | **[[3kjd]], [[3kcz]], [[4tvj]], [[4zzx]], [[4zzy]], [[5dsy]], [[7r52]] - hPARP 2 catalytic domain + inhibitor<br /> | ||
**[[6tx3]] - hPARP 2 catalytic domain + HPF1<br /> | **[[6tx3]] - hPARP 2 catalytic domain + HPF1<br /> | ||
**[[4pjv]] - hPARP 2 α helical and catalytic domain + inhibitor<br /> | **[[4pjv]] - hPARP 2 α helical and catalytic domain + inhibitor<br /> | ||
**[[6f1k]], [[6f5b]], [[6f5f]] - hPARP 2 WGR domain + DNA<br /> | **[[6f1k]], [[6f5b]], [[6f5f]] - hPARP 2 WGR domain + DNA<br /> | ||
| + | **[[7aeo]] - hPARP 2 90-583 + DNA<br /> | ||
**[[5d5k]] - hPARP 2 residues 1-78 + importin subunit -1 <br /> | **[[5d5k]] - hPARP 2 residues 1-78 + importin subunit -1 <br /> | ||
**[[1gs0]] - mPARP 2 catalytic domain - mouse | **[[1gs0]] - mPARP 2 catalytic domain - mouse | ||
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*Poly (ADP-ribose) polymerase 12 | *Poly (ADP-ribose) polymerase 12 | ||
| - | **[[2pqf]] - hPARP-12 catalytic domain + inhibitor | + | **[[2pqf]] - hPARP-12 catalytic domain + inhibitor<br /> |
| + | **[[6v3w]] - hPARP 12 catalytic domain + inhibitor<br /> | ||
| + | |||
| + | *PARP 13 | ||
| + | |||
| + | **[[7sz3]] – mPARP-13 592-789 + ADPr <br /> | ||
| + | **[[7sz2]] – mPARP-13 592-789 + ATP <br /> | ||
*Poly (ADP-ribose) polymerase 14; Domains – WWE 139-224; macro 1 708-898; macro 2 918-1115; macro 3 1208-1388; catalytic 1611-1801 | *Poly (ADP-ribose) polymerase 14; Domains – WWE 139-224; macro 1 708-898; macro 2 918-1115; macro 3 1208-1388; catalytic 1611-1801 | ||
| - | **[[3goy]], [[3se2]], [[3smi]], [[3smj]], [[4f1l]], [[4f1q]], [[4py4]], [[5lxp]], [[5lyh]], [[5nqe]], [[5v7t]], [[5v7w]], [[6g0w]], [[6fym]], [[6fzm]] - hPARP 14 catalytic domain + inhibitor<br /> | + | **[[3goy]], [[3se2]], [[3smi]], [[3smj]], [[4f1l]], [[4f1q]], [[4py4]], [[5lxp]], [[5lyh]], [[5nqe]], [[5v7t]], [[5v7w]], [[6g0w]], [[6fym]], [[6fzm]], [[6we2]], [[6we3]], [[6we4]], [[7l9y]], [[7lun]], [[7r3l]] - hPARP 14 catalytic domain + inhibitor<br /> |
**[[3q6z]] - hPARP-14 macro domain 1+ ADPR<br /> | **[[3q6z]] - hPARP-14 macro domain 1+ ADPR<br /> | ||
**[[3q71]] - hPARP-14 macro domain 2+ ADPR<br /> | **[[3q71]] - hPARP-14 macro domain 2+ ADPR<br /> | ||
**[[5o2d]] - hPARP-14 macro domain 2 (mutant) + inhibitor<br /> | **[[5o2d]] - hPARP-14 macro domain 2 (mutant) + inhibitor<br /> | ||
**[[3vfq]], [[4d86]] - hPARP-14 macro domain 1+2 + ADPR<br /> | **[[3vfq]], [[4d86]] - hPARP-14 macro domain 1+2 + ADPR<br /> | ||
| - | **[[4abl]] - hPARP-14 macro domain 3<br /> | + | **[[4abl]], [[7d2c]] - hPARP-14 macro domain 3<br /> |
**[[4abk]] - hPARP-14 macro domain 3+ ADPR<br /> | **[[4abk]] - hPARP-14 macro domain 3+ ADPR<br /> | ||
| - | **[[5qht]], [[5qhu]], [[ | + | **[[5qht]], [[5qhu]], [[5qhv]], [[5qhw]], [[5qhx]], [[5qhy]], [[5qhz]], [[5qi0]], [[5qi1]], [[5qi2]], [[5qi3]], [[5qi4]], [[5qi5]], [[5qi6]], [[5qi7]], [[5qi8]], [[5qi9]], [[5qia]] - hPARP-14 macro domain 3 + inhibitor<br /> |
**[[1x4r]] - mPARP-14 WWE domain – NMR<br /> | **[[1x4r]] - mPARP-14 WWE domain – NMR<br /> | ||
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**[[3blj]] - hPARP-15 catalytic domain<br /> | **[[3blj]] - hPARP-15 catalytic domain<br /> | ||
**[[4f0e]] - hPARP-15 catalytic domain + ligand<br /> | **[[4f0e]] - hPARP-15 catalytic domain + ligand<br /> | ||
| - | **[[3gey]] - hPARP-15 catalytic domain + inhibitor<br /> | + | **[[3gey]], [[6ry4]], [[7oqq]], [[7osp]], [[7oss]], [[7osx]], [[7otf]], [[7oth]], [[7ouw]], [[7oux]], [[7pw3]], [[7pwa]], [[7pwc]], [[7pwk]], [[7pwl]], [[7pwm]], [[7pwq]], [[7pwp]], [[7pwr]], [[7pws]], [[7pwu]], [[7pww]], [[7px6]], [[7px7]], [[7r3o]], [[7r4a]], [[7r5d]], [[7z1v]], [[7z1w]], [[7z1y]], [[7z1y]], [[7z2q]], [[7z41]] - hPARP-15 catalytic domain + inhibitor<br /> |
| + | **[[7f41]], [[7f42]], [[7f43]] – hPARP-15 catalytic domain + drug<br /> | ||
**[[6ek3]] - hPARP-15 catalytic domain (mutant) + inhibitor<br /> | **[[6ek3]] - hPARP-15 catalytic domain (mutant) + inhibitor<br /> | ||
**[[3v2b]] – hPARP-15 macro domain 2 + ADP<br /> | **[[3v2b]] – hPARP-15 macro domain 2 + ADP<br /> | ||
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**[[4f0d]] - hPARP-16 + aminobenzamide<br /> | **[[4f0d]] - hPARP-16 + aminobenzamide<br /> | ||
| - | **[[6hxr]] - hPARP-16 + inhibitor<br /> | + | **[[6hxr]], [[6w65]] - hPARP-16 + inhibitor<br /> |
**[[6hxs]] - hPARP-16 + CABRA-NAD<br /> | **[[6hxs]] - hPARP-16 + CABRA-NAD<br /> | ||
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**[[5n9q]] – AtPARP Rcd1 residues 468-567 <br /> | **[[5n9q]] – AtPARP Rcd1 residues 468-567 <br /> | ||
| - | * | + | *Tankyrase 1 (SAM domain 1018-1093; catalytic domain 1093-1325) |
**[[5jti]], [[5ju5]], [[5kni]] - hTank 1 SAM domain<br /> | **[[5jti]], [[5ju5]], [[5kni]] - hTank 1 SAM domain<br /> | ||
**[[2rf5]] - hTank 1 catalytic domain (mutant)<br /> | **[[2rf5]] - hTank 1 catalytic domain (mutant)<br /> | ||
**[[3udd]], [[3uh2]], [[3uh4]], [[4dvi]], [[4i9i]], [[4k4e]], [[4k4f]], [[4krs]], [[4li6]], [[4li7]], [[4li8]], [[4msg]], [[4msk]], [[4mt9]], [[4n3r]], [[4n4v]], [[4oa7]], [[4w5s]], [[4w6e]], [[4tor]], [[4u6a]], [[4uuh]], [[4uw1]], [[5ebt]], [[5ece]], [[6qxu]] - hTank 1 catalytic domain + inhibitor<br /> | **[[3udd]], [[3uh2]], [[3uh4]], [[4dvi]], [[4i9i]], [[4k4e]], [[4k4f]], [[4krs]], [[4li6]], [[4li7]], [[4li8]], [[4msg]], [[4msk]], [[4mt9]], [[4n3r]], [[4n4v]], [[4oa7]], [[4w5s]], [[4w6e]], [[4tor]], [[4u6a]], [[4uuh]], [[4uw1]], [[5ebt]], [[5ece]], [[6qxu]] - hTank 1 catalytic domain + inhibitor<br /> | ||
| + | **[[7kkm]], [[7kkn]], [[7kko]], [[7kkp]], [[7kkq]] - hTank 1 catalytic domain + drug<br /> | ||
**[[4tos]], [[5ety]] - hTank 1 catalytic domain (mutant) + inhibitor<br /> | **[[4tos]], [[5ety]] - hTank 1 catalytic domain (mutant) + inhibitor<br /> | ||
**[[5gp7]] - hTank 1 residues 799-957 + USP25<br /> | **[[5gp7]] - hTank 1 residues 799-957 + USP25<br /> | ||
**[[5jhq]] - hTank 1 residues 174-649 + peptide<br /> | **[[5jhq]] - hTank 1 residues 174-649 + peptide<br /> | ||
| + | **[[6uro]], [[6urq]] - hTank 1 residues 328-646 + PAGE-4<br /> | ||
| + | **[[6cf6]] - mTank 1 residues 308-655 + RNF146<br /> | ||
*Tankyrase 2 or PARP 5b (SAM domain 867-940; catalytic domain 946-1113; C-terminal domain 1114-1162) | *Tankyrase 2 or PARP 5b (SAM domain 867-940; catalytic domain 946-1113; C-terminal domain 1114-1162) | ||
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**[[3kr7]] - hTank 2 catalytic domain<br /> | **[[3kr7]] - hTank 2 catalytic domain<br /> | ||
**[[4hki]] - hTank 2 catalytic + C terminal domains<br /> | **[[4hki]] - hTank 2 catalytic + C terminal domains<br /> | ||
| - | **[[3mhk]], [[3mhj]], [[3p0n]], [[3p0p]], [[3p0q]], [[3kr8]], [[3kr8]], [[3u9y]], [[3ua9]], [[3w51]], [[4avu]], [[4avw]], [[4bfp]], [[4bj9]], [[4bjb]], [[4bjc]], [[4bs4]], [[4bu3]], [[4bu5]], [[4bu6]], [[4bu7]], [[4bu8]], [[4bu9]], [[4bua]], [[4bud]], [[4bue]], [[4buf]], [[4bui]], [[4bus]], [[4but]], [[4buu]], [[4buv]], [[4buw]], [[4bux]], [[4buy]], [[4hyf]], [[4iue]], [[4j1z]], [[4j21]], [[4j22]], [[4j3l]], [[4j3m]], [[4m7b]], [[4pml]], [[4pnl]], [[4pnm]], [[4pnn]], [[4pnq]], [[4pnr]], [[4pns]], [[4pnt]], [[4tju]], [[4tjw]], [[4tjy]], [[4tk0]], [[4tk5]], [[4tkf]], [[4tkg]], [[4tki]], [[5aku]], [[5akw]], [[5al1]], [[5al2]], [[5al3]], [[5al4]], [[5al5]], [[4ufu]], [[4uhg]], [[4ui3]], [[4ui4]], [[4ui5]], [[4ui6]], [[4ui7]], [[4ui8]], [[4uvl]], [[4uvn]], [[4uvo]], [[4uvp]], [[4uvs]], [[4uvt]], [[4uvu]], [[4uvv]], [[4uvw]], [[4uvx]], [[4uvy]], [[4uvz]], [[4ux4]], [[4w5i]], [[5adq]], [[5adr]], [[5ads]], [[5adt]], [[5aeh]], [[5owt]], [[5ows]] - hTank 2 catalytic domain+ inhibitor<br /> | + | **[[8aly]] - hTank 2 SAM + catalytic domains – Cryo EM<br /> |
| - | **[[4hkk]], [[4hkn]], [[4hl5]], [[4hlf]], [[4hlg]], [[4hlh]], [[4hlk]], [[4hlm]], [[4hmh]], [[4kzl]], [[4kzq]], [[4kzu]], [[4l09]], [[4l0b]], [[4l0i]], [[4l0s]], [[4l0t]], [[4l0v]], [[4l10]], [[4l2f]], [[4l2g]], [[4l2k]], [[4l31]], [[4l32]], [[4l33]], [[4l34]], [[5c5p]], [[5c5q]], [[5c5r]], [[5dcz]], [[5fpf]], [[5fpg]], [[5nxe]], [[5nwg]], [[5nwd]], [[5nwc]], [[5nwb]] [[5nvh]], [[5nvf]], [[5nve]], [[5nvc]], [[5nut]], [[5nt4]], [[5nt0]], [[5nsx]], [[5nsp]], [[5nob]], [[4ufy]] - hTank 2 catalytic and C terminal domains + inhibitor<br /> | + | **[[3mhk]], [[3mhj]], [[3p0n]], [[3p0p]], [[3p0q]], [[3kr8]], [[3kr8]], [[3u9y]], [[3ua9]], [[3w51]], [[4avu]], [[4avw]], [[4bfp]], [[4bj9]], [[4bjb]], [[4bjc]], [[4bs4]], [[4bu3]], [[4bu5]], [[4bu6]], [[4bu7]], [[4bu8]], [[4bu9]], [[4bua]], [[4bud]], [[4bue]], [[4buf]], [[4bui]], [[4bus]], [[4but]], [[4buu]], [[4buv]], [[4buw]], [[4bux]], [[4buy]], [[4hyf]], [[4iue]], [[4j1z]], [[4j21]], [[4j22]], [[4j3l]], [[4j3m]], [[4m7b]], [[4pml]], [[4pnl]], [[4pnm]], [[4pnn]], [[4pnq]], [[4pnr]], [[4pns]], [[4pnt]], [[4tju]], [[4tjw]], [[4tjy]], [[4tk0]], [[4tk5]], [[4tkf]], [[4tkg]], [[4tki]], [[5aku]], [[5akw]], [[5al1]], [[5al2]], [[5al3]], [[5al4]], [[5al5]], [[4ufu]], [[4uhg]], [[4ui3]], [[4ui4]], [[4ui5]], [[4ui6]], [[4ui7]], [[4ui8]], [[4uvl]], [[4uvn]], [[4uvo]], [[4uvp]], [[4uvs]], [[4uvt]], [[4uvu]], [[4uvv]], [[4uvw]], [[4uvx]], [[4uvy]], [[4uvz]], [[4ux4]], [[4w5i]], [[5adq]], [[5adr]], [[5ads]], [[5adt]], [[5aeh]], [[5owt]], [[5ows]], [[6tg4]], [[6tkm]], [[6tkn]], [[6tkp]], [[6tkq]], [[6tkr]], [[6tks]], [[7ce4]], [[7o6x]], [[7ojo]], [[7olj]], [[7omc]], [[7pox]], [[7r3z]], [[7r5x]] - hTank 2 catalytic domain+ inhibitor<br /> |
| + | **[[7ocv]] - hTank 2 SAM + catalytic domains + inhibitor<br /> | ||
| + | **[[4hkk]], [[4hkn]], [[4hl5]], [[4hlf]], [[4hlg]], [[4hlh]], [[4hlk]], [[4hlm]], [[4hmh]], [[4kzl]], [[4kzq]], [[4kzu]], [[4l09]], [[4l0b]], [[4l0i]], [[4l0s]], [[4l0t]], [[4l0v]], [[4l10]], [[4l2f]], [[4l2g]], [[4l2k]], [[4l31]], [[4l32]], [[4l33]], [[4l34]], [[5c5p]], [[5c5q]], [[5c5r]], [[5dcz]], [[5fpf]], [[5fpg]], [[5nxe]], [[5nwg]], [[5nwd]], [[5nwc]], [[5nwb]] [[5nvh]], [[5nvf]], [[5nve]], [[5nvc]], [[5nut]], [[5nt4]], [[5nt0]], [[5nsx]], [[5nsp]], [[5nob]], [[4ufy]], [[5zqo]], [[5zqp]], [[5zqq]], [[5zqr]], [[6a84]], [[6kro]] - hTank 2 catalytic and C terminal domains + inhibitor<br /> | ||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
3D Structures of Poly (ADP-ribose) polymerase
Updated on 04-September-2023
