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3eml

From Proteopedia

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Current revision (06:29, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3eml' size='340' side='right'caption='[[3eml]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='3eml' size='340' side='right'caption='[[3eml]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3eml]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EML FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3eml]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EML FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene>, <scene name='pdbligand=ZMA:4-{2-[(7-AMINO-2-FURAN-2-YL[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZIN-5-YL)AMINO]ETHYL}PHENOL'>ZMA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene>, <scene name='pdbligand=ZMA:4-{2-[(7-AMINO-2-FURAN-2-YL[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZIN-5-YL)AMINO]ETHYL}PHENOL'>ZMA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eml OCA], [https://pdbe.org/3eml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eml RCSB], [https://www.ebi.ac.uk/pdbsum/3eml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eml ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eml OCA], [https://pdbe.org/3eml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eml RCSB], [https://www.ebi.ac.uk/pdbsum/3eml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eml ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN]] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
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[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Escherichia virus T4]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure]]
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[[Category: Cherezov V]]
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[[Category: Cherezov, V]]
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[[Category: Chien EYT]]
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[[Category: Chien, E Y.T]]
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[[Category: Griffith MT]]
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[[Category: GPCR, GPCR Network]]
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[[Category: Hanson MA]]
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[[Category: Griffith, M T]]
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[[Category: Ijzerman AP]]
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[[Category: Hanson, M A]]
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[[Category: Jaakola V-P]]
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[[Category: Ijzerman, A P]]
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[[Category: Lane JR]]
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[[Category: Jaakola, V P]]
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[[Category: Stevens RC]]
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[[Category: Lane, J R]]
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[[Category: Stevens, R C]]
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[[Category: Accelerated technologies center for gene to 3d structure]]
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[[Category: Adenosine]]
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[[Category: Atcg3d]]
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[[Category: Caffeine]]
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[[Category: Gpcr]]
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[[Category: Gpcr network]]
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[[Category: Lcp]]
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[[Category: Membrane protein]]
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[[Category: Mesophase]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Receptor]]
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[[Category: Structural genomic]]
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Current revision

The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385.

PDB ID 3eml

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