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3fdt

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==Crystal structure of the complex of human chromobox homolog 5 (CBX5) with H3K9(me)3 peptide==
==Crystal structure of the complex of human chromobox homolog 5 (CBX5) with H3K9(me)3 peptide==
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<StructureSection load='3fdt' size='340' side='right' caption='[[3fdt]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3fdt' size='340' side='right'caption='[[3fdt]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fdt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FDT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fdt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FDT FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CBX5, HP1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fdt OCA], [http://pdbe.org/3fdt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fdt RCSB], [http://www.ebi.ac.uk/pdbsum/3fdt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fdt ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fdt OCA], [https://pdbe.org/3fdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fdt RCSB], [https://www.ebi.ac.uk/pdbsum/3fdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fdt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CBX5_HUMAN CBX5_HUMAN]] Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.<ref>PMID:19783980</ref>
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[https://www.uniprot.org/uniprot/CBX5_HUMAN CBX5_HUMAN] Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.<ref>PMID:19783980</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fd/3fdt_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fd/3fdt_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Amaya, M F]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Synthetic construct]]
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[[Category: Bochkarev, A]]
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[[Category: Amaya MF]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A M]]
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[[Category: Bochkarev A]]
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[[Category: Kozieradzki, I]]
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[[Category: Bountra C]]
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[[Category: Loppnau, P]]
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[[Category: Edwards AM]]
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[[Category: Min, J]]
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[[Category: Kozieradzki I]]
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[[Category: Ouyang, H]]
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[[Category: Loppnau P]]
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[[Category: Ravichandran, M]]
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[[Category: Min J]]
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[[Category: Structural genomic]]
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[[Category: Ouyang H]]
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[[Category: Weigelt, J]]
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[[Category: Ravichandran M]]
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[[Category: Cbx5]]
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[[Category: Weigelt J]]
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[[Category: Centromere]]
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[[Category: Chromobox homolog5]]
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[[Category: Chromosomal protein]]
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[[Category: Dna-binding]]
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[[Category: Nucleosome core]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein binding]]
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[[Category: Sgc]]
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Current revision

Crystal structure of the complex of human chromobox homolog 5 (CBX5) with H3K9(me)3 peptide

PDB ID 3fdt

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