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3ff9

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==Structure of NK cell receptor KLRG1==
==Structure of NK cell receptor KLRG1==
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<StructureSection load='3ff9' size='340' side='right' caption='[[3ff9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='3ff9' size='340' side='right'caption='[[3ff9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ff9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FF9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FF9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ff9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FF9 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ff7|3ff7]], [[3ff8|3ff8]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Klrg1, Mafa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ff9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ff9 OCA], [https://pdbe.org/3ff9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ff9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ff9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ff9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ff9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ff9 OCA], [http://pdbe.org/3ff9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ff9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ff9 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KLRG1_MOUSE KLRG1_MOUSE]] Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.<ref>PMID:19604491</ref>
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[https://www.uniprot.org/uniprot/KLRG1_MOUSE KLRG1_MOUSE] Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.<ref>PMID:19604491</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/3ff9_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/3ff9_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Li, Y]]
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[[Category: Mus musculus]]
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[[Category: Mariuzza, R A]]
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[[Category: Li Y]]
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[[Category: Glycoprotein]]
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[[Category: Mariuzza RA]]
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[[Category: Immune system]]
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[[Category: Lectin]]
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[[Category: Membrane]]
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[[Category: Natural killer cell receptor kltg1]]
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[[Category: Phosphoprotein]]
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[[Category: Receptor]]
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[[Category: Signal-anchor]]
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[[Category: Transmembrane]]
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Current revision

Structure of NK cell receptor KLRG1

PDB ID 3ff9

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