3fxd

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{{Seed}}
 
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[[Image:3fxd.png|left|200px]]
 
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==Crystal structure of interacting domains of IcmR and IcmQ==
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The line below this paragraph, containing "STRUCTURE_3fxd", creates the "Structure Box" on the page.
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<StructureSection load='3fxd' size='340' side='right'caption='[[3fxd]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fxd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_str._Corby Legionella pneumophila str. Corby] and [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._Philadelphia_1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FXD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fxd OCA], [https://pdbe.org/3fxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fxd RCSB], [https://www.ebi.ac.uk/pdbsum/3fxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fxd ProSAT]</span></td></tr>
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{{STRUCTURE_3fxd| PDB=3fxd | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5ZYC9_LEGPH Q5ZYC9_LEGPH]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/3fxd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fxd ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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During infection, Legionella pneumophila creates a replication vacuole within eukaryotic cells and this requires a Type IVb secretion system (T4bSS). IcmQ plays a critical role in the translocase and associates with IcmR. In this paper, we show that the N-terminal domain of IcmQ (Qn) mediates self-dimerization, whereas the C-terminal domain with a basic linker promotes membrane association. In addition, the binding of IcmR to IcmQ prevents self-dimerization and also blocks membrane permeabilization. However, IcmR does not completely block membrane binding by IcmQ. We then determined crystal structures of Qn with the interacting region of IcmR. In this complex, each protein forms an alpha-helical hairpin within a parallel four-helix bundle. The amphipathic nature of helices in Qn suggests two possible models for membrane permeabilization by IcmQ. The Rm-Qn structure also suggests how IcmR-like proteins in other L. pneumophila species may interact with their IcmQ partners.
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===Crystal structure of interacting domains of IcmR and IcmQ===
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Structure and function of interacting IcmR-IcmQ domains from a type IVb secretion system in Legionella pneumophila.,Raychaudhury S, Farelli JD, Montminy TP, Matthews M, Menetret JF, Dumenil G, Roy CR, Head JF, Isberg RR, Akey CW Structure. 2009 Apr 15;17(4):590-601. PMID:19368892<ref>PMID:19368892</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19368892}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3fxd" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19368892 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19368892}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3FXD is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Legionella_pneumophila_str._corby Legionella pneumophila str. corby] and [http://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._philadelphia_1 Legionella pneumophila subsp. pneumophila str. philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FXD OCA].
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[[Category: Legionella pneumophila str. Corby]]
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[[Category: Legionella pneumophila subsp. pneumophila str. Philadelphia 1]]
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==Reference==
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[[Category: Akey CW]]
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<ref group="xtra">PMID:19368892</ref><references group="xtra"/>
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[[Category: Head JF]]
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[[Category: Legionella pneumophila str. corby]]
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[[Category: Raychaudhury S]]
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[[Category: Legionella pneumophila subsp. pneumophila str. philadelphia 1]]
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[[Category: Akey, C W.]]
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[[Category: Head, J F.]]
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[[Category: Raychaudhury, S.]]
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[[Category: 4 helix bundle]]
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[[Category: Helix-turn-helix]]
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[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:53:49 2009''
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Current revision

Crystal structure of interacting domains of IcmR and IcmQ

PDB ID 3fxd

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