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3g6r

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==GR DNA binding domain:FKBP5 complex-52, 18bp==
==GR DNA binding domain:FKBP5 complex-52, 18bp==
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<StructureSection load='3g6r' size='340' side='right' caption='[[3g6r]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='3g6r' size='340' side='right'caption='[[3g6r]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3g6r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G6R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3g6r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G6R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fyl|3fyl]], [[3g6q|3g6q]], [[3g6p|3g6p]], [[3g6t|3g6t]], [[3g6u|3g6u]], [[3g8x|3g8x]], [[3g97|3g97]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Grl, Nr3c1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g6r OCA], [https://pdbe.org/3g6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g6r RCSB], [https://www.ebi.ac.uk/pdbsum/3g6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g6r ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g6r OCA], [http://pdbe.org/3g6r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g6r RCSB], [http://www.ebi.ac.uk/pdbsum/3g6r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g6r ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GCR_RAT GCR_RAT]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation (By similarity).<ref>PMID:12917342</ref>
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[https://www.uniprot.org/uniprot/GCR_RAT GCR_RAT] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation (By similarity).<ref>PMID:12917342</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/3g6r_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/3g6r_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3g6r" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3g6r" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glucocorticoid receptor|Glucocorticoid receptor]]
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*[[Glucocorticoid receptor 3D structures|Glucocorticoid receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Large Structures]]
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[[Category: Meijsing, S H]]
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[[Category: Rattus norvegicus]]
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[[Category: Pufall, M A]]
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[[Category: Meijsing SH]]
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[[Category: Yamamoto, K R]]
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[[Category: Pufall MA]]
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[[Category: Allostery]]
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[[Category: Yamamoto KR]]
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[[Category: Alternative initiation]]
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[[Category: Chromatin regulator]]
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[[Category: Cytoplasm]]
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[[Category: Dna-binding]]
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[[Category: Glucocorticoid]]
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[[Category: Hormone]]
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[[Category: Lever arm]]
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[[Category: Lipid-binding]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Receptor]]
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[[Category: Steroid-binding]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription-dna complex]]
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[[Category: Ubl conjugation]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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Current revision

GR DNA binding domain:FKBP5 complex-52, 18bp

PDB ID 3g6r

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