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3gj7

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Current revision (07:07, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3gj7' size='340' side='right'caption='[[3gj7]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
<StructureSection load='3gj7' size='340' side='right'caption='[[3gj7]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3gj7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GJ7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3gj7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GJ7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ch5|3ch5]], [[2gqe|2gqe]], [[1byu|1byu]], [[3gj0|3gj0]], [[3gj3|3gj3]], [[3gj4|3gj4]], [[3gj5|3gj5]], [[3gj6|3gj6]], [[3gj8|3gj8]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAN, ARA24, OK/SW-cl.81 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Nup153 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gj7 OCA], [https://pdbe.org/3gj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gj7 RCSB], [https://www.ebi.ac.uk/pdbsum/3gj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gj7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gj7 OCA], [https://pdbe.org/3gj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gj7 RCSB], [https://www.ebi.ac.uk/pdbsum/3gj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gj7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[https://www.uniprot.org/uniprot/NU153_RAT NU153_RAT]] Possible DNA-binding subunit of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane.
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[https://www.uniprot.org/uniprot/NU153_RAT NU153_RAT] Possible DNA-binding subunit of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Partridge, J R]]
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[[Category: Rattus norvegicus]]
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[[Category: Schwartz, T U]]
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[[Category: Partridge JR]]
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[[Category: Acetylation]]
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[[Category: Schwartz TU]]
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[[Category: Cytoplasm]]
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[[Category: Dna-binding]]
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[[Category: G protein]]
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[[Category: Gdp]]
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[[Category: Gtp-binding]]
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[[Category: Host-virus interaction]]
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[[Category: Isopeptide bond]]
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[[Category: Metal-binding]]
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[[Category: Mrna transport]]
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[[Category: Nuclear pore]]
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[[Category: Nuclear pore complex]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Nup153]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Protein transport]]
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[[Category: Ran]]
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[[Category: Translocation]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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[[Category: Ubl conjugation]]
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[[Category: Zinc]]
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[[Category: Zinc finger]]
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[[Category: Zinc-finger]]
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Current revision

Crystal structure of human RanGDP-Nup153ZnF12 complex

PDB ID 3gj7

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