3gzh

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{{Seed}}
 
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[[Image:3gzh.png|left|200px]]
 
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==Crystal structure of phosphate-bound adenylosuccinate lyase from E. coli==
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The line below this paragraph, containing "STRUCTURE_3gzh", creates the "Structure Box" on the page.
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<StructureSection load='3gzh' size='340' side='right'caption='[[3gzh]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3gzh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GZH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_3gzh| PDB=3gzh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gzh OCA], [https://pdbe.org/3gzh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gzh RCSB], [https://www.ebi.ac.uk/pdbsum/3gzh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gzh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8X737_ECO57 Q8X737_ECO57]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/3gzh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gzh ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Adenylosuccinate lyase (ASL) is an enzyme from the purine-biosynthetic pathway that catalyzes the cleavage of 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) to 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) and fumarate. ASL is also responsible for the conversion of succinyladenosine monophosphate (SAMP) to adenosine monophosphate (AMP) and fumarate. Here, the crystal structure of adenylosuccinate lyase from Escherichia coli was determined to 1.9 A resolution. The enzyme adopts a substrate-bound conformation as a result of the presence of two phosphate ions bound in the active site. Comparison with previously solved structures of the apoenzyme and an SAMP-bound H171A mutant reveals a conformational change at His171 associated with substrate binding and confirms the role of this residue as a catalytic acid.
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===Crystal structure of phosphate-bound adenylosuccinate lyase from E. coli===
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The structure of phosphate-bound Escherichia coli adenylosuccinate lyase identifies His171 as a catalytic acid.,Kozlov G, Nguyen L, Pearsall J, Gehring K Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Sep 1;65(Pt, 9):857-61. Epub 2009 Aug 20. PMID:19724117<ref>PMID:19724117</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3gzh" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19724117}}, adds the Publication Abstract to the page
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*[[Adenylosuccinate lyase 3D structures|Adenylosuccinate lyase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19724117 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19724117}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli O157:H7]]
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3GZH is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o157:h7 Escherichia coli o157:h7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GZH OCA].
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[[Category: Large Structures]]
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[[Category: Gehring K]]
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==Reference==
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[[Category: Kozlov G]]
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<ref group="xtra">PMID:19724117</ref><references group="xtra"/>
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[[Category: Adenylosuccinate lyase]]
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[[Category: Escherichia coli o157:h7]]
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[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]
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[[Category: Gehring, K.]]
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[[Category: Kozlov, G.]]
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[[Category: Adenylosuccinate lyase]]
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[[Category: All-helical fold]]
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[[Category: Bacterial structural genomics initiative]]
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[[Category: Bsgi]]
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[[Category: Lyase]]
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[[Category: Montreal-kingston bacterial structural genomics initiative]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 19:26:47 2009''
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Current revision

Crystal structure of phosphate-bound adenylosuccinate lyase from E. coli

PDB ID 3gzh

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