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3h2m

From Proteopedia

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==Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase==
==Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase==
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<StructureSection load='3h2m' size='340' side='right' caption='[[3h2m]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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<StructureSection load='3h2m' size='340' side='right'caption='[[3h2m]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3h2m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_a2012 Bacillus anthracis a2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H2M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3h2m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._A2012 Bacillus anthracis str. A2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H2M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B61:2-AMINO-6-(2-HYDROXY-2-METHYLPROPYL)-8-METHYL-7,8-DIHYDROPTERIDIN-4(3H)-ONE'>B61</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tww|1tww]], [[1twz|1twz]], [[1tx0|1tx0]], [[1tx2|1tx2]], [[1tws|1tws]], [[3h21|3h21]], [[3h22|3h22]], [[3h23|3h23]], [[3h24|3h24]], [[3h26|3h26]], [[3h2a|3h2a]], [[3h2c|3h2c]], [[3h2e|3h2e]], [[3h2f|3h2f]], [[3h2n|3h2n]], [[3h2o|3h2o]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B61:2-AMINO-6-(2-HYDROXY-2-METHYLPROPYL)-8-METHYL-7,8-DIHYDROPTERIDIN-4(3H)-ONE'>B61</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folP, BAO_0074 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=191218 Bacillus anthracis A2012])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h2m OCA], [https://pdbe.org/3h2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h2m RCSB], [https://www.ebi.ac.uk/pdbsum/3h2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h2m ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h2m OCA], [http://pdbe.org/3h2m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h2m RCSB], [http://www.ebi.ac.uk/pdbsum/3h2m PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q81VW8_BACAN Q81VW8_BACAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h2/3h2m_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h2/3h2m_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Dihydropteroate synthase|Dihydropteroate synthase]]
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*[[Dihydropteroate synthase 3D structures|Dihydropteroate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus anthracis a2012]]
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[[Category: Bacillus anthracis str. A2012]]
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[[Category: Dihydropteroate synthase]]
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[[Category: Large Structures]]
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[[Category: White, S W]]
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[[Category: White SW]]
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[[Category: Yun, M K]]
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[[Category: Yun M-K]]
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[[Category: Anthracis]]
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[[Category: Dihydropteroate]]
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[[Category: Folate biosynthesis]]
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[[Category: Pterine]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase

PDB ID 3h2m

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