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3h9f

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==Crystal Structure of Human Dual Specificity Protein Kinase (TTK) in complex with a pyrimido-diazepin ligand==
==Crystal Structure of Human Dual Specificity Protein Kinase (TTK) in complex with a pyrimido-diazepin ligand==
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<StructureSection load='3h9f' size='340' side='right' caption='[[3h9f]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='3h9f' size='340' side='right'caption='[[3h9f]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3h9f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H9F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H9F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3h9f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H9F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=92M:9-CYCLOPENTYL-2-(4-(4-HYDROXYPIPERIDIN-1-YL)-2-METHOXYPHENYLAMINO)-5-METHYL-8,9-DIHYDRO-5H-PYRIMIDO[4,5-B][1,4]DIAZEPIN-6(7H)-ONE'>92M</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=92M:9-CYCLOPENTYL-2-(4-(4-HYDROXYPIPERIDIN-1-YL)-2-METHOXYPHENYLAMINO)-5-METHYL-8,9-DIHYDRO-5H-PYRIMIDO[4,5-B][1,4]DIAZEPIN-6(7H)-ONE'>92M</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MPS1L1, TTK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h9f OCA], [https://pdbe.org/3h9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h9f RCSB], [https://www.ebi.ac.uk/pdbsum/3h9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h9f ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h9f OCA], [http://pdbe.org/3h9f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h9f RCSB], [http://www.ebi.ac.uk/pdbsum/3h9f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3h9f ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
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[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Dual specificity protein kinase|Dual specificity protein kinase]]
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*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dual-specificity kinase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Chaikuad, A]]
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[[Category: Chaikuad A]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Elkins JM]]
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[[Category: Elkins, J M]]
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[[Category: Fedorov O]]
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[[Category: Fedorov, O]]
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[[Category: Filippakopoulos P]]
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[[Category: Filippakopoulos, P]]
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[[Category: Gray NS]]
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[[Category: Gray, N S]]
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[[Category: Keates T]]
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[[Category: Keates, T]]
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[[Category: King O]]
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[[Category: King, O]]
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[[Category: Knapp S]]
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[[Category: Knapp, S]]
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[[Category: Kwiatkowski N]]
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[[Category: Kwiatkowski, N]]
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[[Category: Picaud SS]]
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[[Category: Picaud, S S]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W]]
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[[Category: Soundararajan M]]
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[[Category: Structural genomic]]
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[[Category: Weigelt J]]
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[[Category: Soundararajan, M]]
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[[Category: Yue W]]
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[[Category: Weigelt, J]]
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[[Category: Von Delft F]]
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[[Category: Yue, W]]
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[[Category: Atp-binding]]
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[[Category: Dual specificity]]
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[[Category: Esk]]
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[[Category: Hmps1]]
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[[Category: Kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Phosphotyrosine picked threonine kinase]]
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[[Category: Pyt]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Sgc]]
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[[Category: Transferase]]
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[[Category: Ttk]]
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[[Category: Tyrosine-protein kinase]]
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Current revision

Crystal Structure of Human Dual Specificity Protein Kinase (TTK) in complex with a pyrimido-diazepin ligand

PDB ID 3h9f

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