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3hfs

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==Structure of apo anthocyanidin reductase from vitis vinifera==
==Structure of apo anthocyanidin reductase from vitis vinifera==
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<StructureSection load='3hfs' size='340' side='right' caption='[[3hfs]], [[Resolution|resolution]] 3.17&Aring;' scene=''>
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<StructureSection load='3hfs' size='340' side='right'caption='[[3hfs]], [[Resolution|resolution]] 3.17&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hfs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Grape Grape]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HFS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hfs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vitis_vinifera Vitis vinifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HFS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.17&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2rh8|2rh8]], [[3dvy|3dvy]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VvANR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29760 Grape])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hfs OCA], [https://pdbe.org/3hfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hfs RCSB], [https://www.ebi.ac.uk/pdbsum/3hfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hfs ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Anthocyanidin_reductase Anthocyanidin reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.77 1.3.1.77] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hfs OCA], [http://pdbe.org/3hfs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hfs RCSB], [http://www.ebi.ac.uk/pdbsum/3hfs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hfs ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ANRCS_VITVI ANRCS_VITVI] Produces the terminal flavan-3-ol monomers required for the formation of proanthocyanidins or condensed tannins in leaves and flowers, as well as in the skin and seeds of developing berries (Ref.1, PubMed:16169968). Behaves as a reductase and as a C-3 epimerase (PubMed:20030585). Catalyzes the double reduction of anthocyanidins, producing a mixture of (2S,3S)- and (2S,3R)-flavan-3-ols (Ref.1). The enzyme catalyzes sequential hydride transfers to C-2 and C-4, respectively and epimerization at C-3 is achieved by tautomerization that occurs between the two hydride transfers (PubMed:20030585). Converts cyanidin, pelargonidin and delphinidin into catechin and epicatechin, afzelechin and epiafzelechin, and gallocatechin and epigallocatechin respectively (PubMed:19690377).<ref>PMID:16169968</ref> <ref>PMID:19690377</ref> <ref>PMID:20030585</ref> [UniProtKB:A0A059TC02]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Anthocyanidin reductase]]
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[[Category: Large Structures]]
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[[Category: Grape]]
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[[Category: Vitis vinifera]]
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[[Category: Estaintot, B Langlois d]]
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[[Category: Gallois B]]
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[[Category: Gallois, B]]
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[[Category: Gargouri M]]
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[[Category: Gargouri, M]]
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[[Category: Granier T]]
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[[Category: Granier, T]]
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[[Category: Langlois d'Estaintot B]]
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[[Category: Manigan, C]]
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[[Category: Manigan C]]
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[[Category: Mauge, C]]
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[[Category: Mauge C]]
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[[Category: Flavonoid]]
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[[Category: Oxidoreductase]]
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[[Category: Rossmann fold]]
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[[Category: Short chain dehydrogenase reductase]]
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Current revision

Structure of apo anthocyanidin reductase from vitis vinifera

PDB ID 3hfs

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