This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3hfv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:21, 6 September 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal structure of human mitochondrial phenylalanyl-tRNA synthetase complexed with m-tyrosine==
==Crystal structure of human mitochondrial phenylalanyl-tRNA synthetase complexed with m-tyrosine==
-
<StructureSection load='3hfv' size='340' side='right' caption='[[3hfv]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+
<StructureSection load='3hfv' size='340' side='right'caption='[[3hfv]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3hfv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HFV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HFV FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3hfv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HFV FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTY:META-TYROSINE'>MTY</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3cmq|3cmq]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTY:META-TYROSINE'>MTY</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FARS2, FARS1, HSPC320 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hfv OCA], [https://pdbe.org/3hfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hfv RCSB], [https://www.ebi.ac.uk/pdbsum/3hfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hfv ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine--tRNA_ligase Phenylalanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.20 6.1.1.20] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hfv OCA], [http://pdbe.org/3hfv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hfv RCSB], [http://www.ebi.ac.uk/pdbsum/3hfv PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/SYFM_HUMAN SYFM_HUMAN]] Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins.<ref>PMID:19549855</ref>
+
[https://www.uniprot.org/uniprot/SYFM_HUMAN SYFM_HUMAN] Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins.<ref>PMID:19549855</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hf/3hfv_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hf/3hfv_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 30: Line 29:
</div>
</div>
<div class="pdbe-citations 3hfv" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3hfv" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Phenylalanine--tRNA ligase]]
+
[[Category: Large Structures]]
-
[[Category: Kessler, N]]
+
[[Category: Kessler N]]
-
[[Category: Klipcan, L]]
+
[[Category: Klipcan L]]
-
[[Category: Moor, N]]
+
[[Category: Moor N]]
-
[[Category: Safro, M G]]
+
[[Category: Safro MG]]
-
[[Category: Aminoacyl-trna synthetase]]
+
-
[[Category: Atp-binding]]
+
-
[[Category: Classii aarss fold]]
+
-
[[Category: Ligase]]
+
-
[[Category: M-tyrosine]]
+
-
[[Category: Mitochondrion]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Protein biosynthesis]]
+
-
[[Category: Rna recogntion]]
+
-
[[Category: Rrm domain]]
+
-
[[Category: Transit peptide]]
+
-
[[Category: Trna]]
+

Current revision

Crystal structure of human mitochondrial phenylalanyl-tRNA synthetase complexed with m-tyrosine

PDB ID 3hfv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3hfv"
Personal tools