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3hr4
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==Human iNOS Reductase and Calmodulin Complex== | ==Human iNOS Reductase and Calmodulin Complex== | ||
| - | <StructureSection load='3hr4' size='340' side='right' caption='[[3hr4]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='3hr4' size='340' side='right'caption='[[3hr4]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3hr4]] is a 8 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3hr4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HR4 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hr4 OCA], [https://pdbe.org/3hr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hr4 RCSB], [https://www.ebi.ac.uk/pdbsum/3hr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hr4 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/NOS2_HUMAN NOS2_HUMAN] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Calmodulin|Calmodulin]] | + | *[[Calmodulin 3D structures|Calmodulin 3D structures]] |
| - | *[[Nitric Oxide Synthase|Nitric Oxide Synthase]] | + | *[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Iyanaki | + | [[Category: Large Structures]] |
| - | [[Category: Kim | + | [[Category: Iyanaki T]] |
| - | [[Category: Misra | + | [[Category: Kim JJK]] |
| - | [[Category: Xia | + | [[Category: Misra I]] |
| - | + | [[Category: Xia C]] | |
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Current revision
Human iNOS Reductase and Calmodulin Complex
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Categories: Homo sapiens | Large Structures | Iyanaki T | Kim JJK | Misra I | Xia C
