1mp6
From Proteopedia
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[[Image:1mp6.jpg|left|200px]] | [[Image:1mp6.jpg|left|200px]] | ||
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'''Structure of the transmembrane region of the M2 protein H+ channel by solid state NMR spectroscopy''' | '''Structure of the transmembrane region of the M2 protein H+ channel by solid state NMR spectroscopy''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1MP6 is a [[Single protein]] structure | + | 1MP6 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MP6 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Kovacs, F.]] | [[Category: Kovacs, F.]] | ||
[[Category: Wang, J.]] | [[Category: Wang, J.]] | ||
| - | [[Category: | + | [[Category: Influenza a virus]] |
| - | [[Category: | + | [[Category: M2 proton channel]] |
| - | [[Category: | + | [[Category: Membrane protein structure]] |
| - | [[Category: | + | [[Category: Solid state nmr]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:32:58 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 22:33, 2 May 2008
Structure of the transmembrane region of the M2 protein H+ channel by solid state NMR spectroscopy
Overview
The transmembrane domain of the M2 protein from influenza A virus forms a nearly uniform and ideal helix in a liquid crystalline bilayer environment. The exposure of the hydrophilic backbone structure is minimized through uniform hydrogen bond geometry imposed by the low dielectric lipid environment. A high-resolution structure of the monomer backbone and a detailed description of its orientation with respect to the bilayer were achieved using orientational restraints from solid-state NMR. With this unique information, the tetrameric structure of this H(+) channel is constrained substantially. Features of numerous published models are discussed in light of the experimental structure of the monomer and derived features of the tetrameric bundle.
About this Structure
1MP6 is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Structure of the transmembrane region of the M2 protein H(+) channel., Wang J, Kim S, Kovacs F, Cross TA, Protein Sci. 2001 Nov;10(11):2241-50. PMID:11604531 Page seeded by OCA on Sat May 3 01:32:58 2008
