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3ifq

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{{Seed}}
 
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[[Image:3ifq.jpg|left|200px]]
 
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==Interction of plakoglobin and beta-catenin with desmosomal cadherins==
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The line below this paragraph, containing "STRUCTURE_3ifq", creates the "Structure Box" on the page.
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<StructureSection load='3ifq' size='340' side='right'caption='[[3ifq]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ifq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IFQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IFQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3ifq| PDB=3ifq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ifq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ifq OCA], [https://pdbe.org/3ifq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ifq RCSB], [https://www.ebi.ac.uk/pdbsum/3ifq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ifq ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PLAK_HUMAN PLAK_HUMAN] Defects in JUP are the cause of Naxos disease (NXD) [MIM:[https://omim.org/entry/601214 601214]. NXD is an autosomal recessive disorder combining diffuse non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular dysplasia/cardiomyopathy and woolly hair.<ref>PMID:10902626</ref> Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:[https://omim.org/entry/611528 611528]; also called arrhythmogenic right ventricular cardiomyopathy 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.<ref>PMID:10902626</ref> <ref>PMID:17924338</ref> <ref>PMID:20031617</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PLAK_HUMAN PLAK_HUMAN] Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/3ifq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ifq ConSurf].
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<div style="clear:both"></div>
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===Interction of plakoglobin and beta-catenin with desmosomal cadherins===
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==See Also==
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*[[Cadherin 3D structures|Cadherin 3D structures]]
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*[[Catenin 3D structures|Catenin 3D structures]]
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==About this Structure==
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== References ==
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3IFQ is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IFQ OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Choi, H J.]]
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[[Category: Choi H-J]]
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[[Category: Gross, J C.]]
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[[Category: Gross JC]]
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[[Category: Pokutta, S.]]
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[[Category: Pokutta S]]
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[[Category: Weis, W I.]]
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[[Category: Weis WI]]
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[[Category: Acetylation]]
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[[Category: Armadillo repeat]]
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[[Category: Calcium]]
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[[Category: Cardiomyopathy]]
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[[Category: Cell adhesion]]
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[[Category: Cell junction]]
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[[Category: Cell membrane]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Cytoplasm]]
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[[Category: Cytoskeleton]]
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[[Category: Disease mutation]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Membrane]]
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[[Category: Palmoplantar keratoderma]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 09:12:20 2009''
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Current revision

Interction of plakoglobin and beta-catenin with desmosomal cadherins

PDB ID 3ifq

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