This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3ioi

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:54, 6 September 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='3ioi' size='340' side='right'caption='[[3ioi]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
<StructureSection load='3ioi' size='340' side='right'caption='[[3ioi]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3ioi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IOI FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3ioi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IOI FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GW:5-(2-FORMYLTHIEN-5-YL)-URIDINE-5-DIPHOSPHATE-ALPHA-D-GALACTOSE'>1GW</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ioh|3ioh]], [[3ioj|3ioj]], [[1lz0|1lz0]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GW:5-(2-FORMYLTHIEN-5-YL)-URIDINE-5-DIPHOSPHATE-ALPHA-D-GALACTOSE'>1GW</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABO ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ioi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ioi OCA], [https://pdbe.org/3ioi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ioi RCSB], [https://www.ebi.ac.uk/pdbsum/3ioi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ioi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ioi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ioi OCA], [https://pdbe.org/3ioi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ioi RCSB], [https://www.ebi.ac.uk/pdbsum/3ioi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ioi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
+
[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 37: Line 36:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Jorgensen, R]]
+
[[Category: Jorgensen R]]
-
[[Category: Palcic, M M]]
+
[[Category: Palcic MM]]
-
[[Category: Pesnot, T]]
+
[[Category: Pesnot T]]
-
[[Category: Wagner, G K]]
+
[[Category: Wagner GK]]
-
[[Category: Abo]]
+
-
[[Category: Blood group antigen]]
+
-
[[Category: Cisab mutant]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Glycosyltransferase]]
+
-
[[Category: Golgi apparatus]]
+
-
[[Category: Gta]]
+
-
[[Category: Inhibitor]]
+
-
[[Category: Manganese]]
+
-
[[Category: Membrane]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Rossmann fold]]
+
-
[[Category: Secreted]]
+
-
[[Category: Semi-closed conformation]]
+
-
[[Category: Signal-anchor]]
+
-
[[Category: Transferase]]
+
-
[[Category: Transmembrane]]
+

Current revision

Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-Gal derived inhibitor (1GW)

PDB ID 3ioi

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ioi"
Personal tools