1mpg

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[[Image:1mpg.gif|left|200px]]
[[Image:1mpg.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1mpg |SIZE=350|CAPTION= <scene name='initialview01'>1mpg</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1mpg", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-3-methyladenine_glycosylase_II DNA-3-methyladenine glycosylase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.21 3.2.2.21] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ALKA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1mpg| PDB=1mpg | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mpg OCA], [http://www.ebi.ac.uk/pdbsum/1mpg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mpg RCSB]</span>
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}}
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'''3-METHYLADENINE DNA GLYCOSYLASE II FROM ESCHERICHIA COLI'''
'''3-METHYLADENINE DNA GLYCOSYLASE II FROM ESCHERICHIA COLI'''
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[[Category: Schaerer, O D.]]
[[Category: Schaerer, O D.]]
[[Category: Verdine, G L.]]
[[Category: Verdine, G L.]]
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[[Category: alka]]
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[[Category: Alka]]
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[[Category: base excision]]
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[[Category: Base excision]]
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[[Category: dna glycosylase]]
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[[Category: Dna glycosylase]]
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[[Category: dna repair]]
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[[Category: Dna repair]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: methylation]]
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[[Category: Methylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:33:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:19:21 2008''
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Revision as of 22:33, 2 May 2008

Image:1mpg.gif

Template:STRUCTURE 1mpg

3-METHYLADENINE DNA GLYCOSYLASE II FROM ESCHERICHIA COLI


Overview

Base-excision DNA repair proteins that target alkylation damage act on a variety of seemingly dissimilar adducts, yet fail to recognize other closely related lesions. The 1.8 A crystal structure of the monofunctional DNA glycosylase AlkA (E. coli 3-methyladenine-DNA glycosylase II) reveals a large hydrophobic cleft unusually rich in aromatic residues. An Asp residue projecting into this cleft is essential for catalysis, and it governs binding specificity for mechanism-based inhibitors. We propose that AlkA recognizes electron-deficient methylated bases through pi-donor/acceptor interactions involving the electron-rich aromatic cleft. Remarkably, AlkA is similar in fold and active site location to the bifunctional glycosylase/lyase endonuclease III, suggesting the two may employ fundamentally related mechanisms for base excision.

About this Structure

1MPG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis for the excision repair of alkylation-damaged DNA., Labahn J, Scharer OD, Long A, Ezaz-Nikpay K, Verdine GL, Ellenberger TE, Cell. 1996 Jul 26;86(2):321-9. PMID:8706136 Page seeded by OCA on Sat May 3 01:33:38 2008

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