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3iv5

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==Crystal structure of Fis bound to 27 bp optimal binding sequence F1==
==Crystal structure of Fis bound to 27 bp optimal binding sequence F1==
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<StructureSection load='3iv5' size='340' side='right' caption='[[3iv5]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='3iv5' size='340' side='right'caption='[[3iv5]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3iv5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IV5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3iv5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IV5 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3jr9|3jr9]], [[3jra|3jra]], [[3jrb|3jrb]], [[3jrc|3jrc]], [[3jrd|3jrd]], [[3jre|3jre]], [[3jrf|3jrf]], [[3jrg|3jrg]], [[3jrh|3jrh]], [[3jri|3jri]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fis, b3261, JW3229 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iv5 OCA], [https://pdbe.org/3iv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iv5 RCSB], [https://www.ebi.ac.uk/pdbsum/3iv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iv5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iv5 OCA], [http://pdbe.org/3iv5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iv5 RCSB], [http://www.ebi.ac.uk/pdbsum/3iv5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iv5 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FIS_ECOLI FIS_ECOLI]] Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin-mediated DNA inversion. Prevents initiation of DNA replication from oriC.<ref>PMID:2209559</ref> <ref>PMID:8836178</ref>
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[https://www.uniprot.org/uniprot/FIS_ECOLI FIS_ECOLI] Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin-mediated DNA inversion. Prevents initiation of DNA replication from oriC.<ref>PMID:2209559</ref> <ref>PMID:8836178</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iv/3iv5_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iv/3iv5_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Cascio, D]]
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[[Category: Large Structures]]
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[[Category: Johnson, R C]]
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[[Category: Cascio D]]
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[[Category: Stella, S]]
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[[Category: Johnson RC]]
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[[Category: Activator]]
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[[Category: Stella S]]
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[[Category: Dna bending]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Dna-binding]]
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[[Category: Hth domain]]
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[[Category: Indirect recognition]]
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[[Category: Minor groove compression]]
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[[Category: Protein-dna complex]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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Current revision

Crystal structure of Fis bound to 27 bp optimal binding sequence F1

PDB ID 3iv5

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OCA

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