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3jtd

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==Calcium-free Scallop Myosin Regulatory Domain with ELC-D19A Point Mutation==
==Calcium-free Scallop Myosin Regulatory Domain with ELC-D19A Point Mutation==
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<StructureSection load='3jtd' size='340' side='right' caption='[[3jtd]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
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<StructureSection load='3jtd' size='340' side='right'caption='[[3jtd]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3jtd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JTD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3jtd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JTD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jtd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jtd RCSB], [http://www.ebi.ac.uk/pdbsum/3jtd PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jtd OCA], [https://pdbe.org/3jtd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jtd RCSB], [https://www.ebi.ac.uk/pdbsum/3jtd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jtd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MYS_AEQIR MYS_AEQIR]] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin. [[http://www.uniprot.org/uniprot/MLE_AEQIR MLE_AEQIR]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity. [[http://www.uniprot.org/uniprot/MLR_AEQIR MLR_AEQIR]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity.
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[https://www.uniprot.org/uniprot/MYS_ARGIR MYS_ARGIR] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/3jtd_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/3jtd_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jtd ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3jtd" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Myosin|Myosin]]
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*[[Myosin 3D Structures|Myosin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Argopecten irradians]]
[[Category: Argopecten irradians]]
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[[Category: Cohen, C]]
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[[Category: Large Structures]]
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[[Category: Himmel, D M]]
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[[Category: Cohen C]]
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[[Category: Mui, S]]
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[[Category: Himmel DM]]
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[[Category: Neall-Hennessey, E O]]
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[[Category: Mui S]]
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[[Category: Szent-Gyorgyi, A]]
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[[Category: O'Neall-Hennessey E]]
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[[Category: Actin-binding]]
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[[Category: Szent-Gyorgyi A]]
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[[Category: Atp-binding]]
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[[Category: Calmodulin-binding]]
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[[Category: Contractile protein]]
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[[Category: Motor protein]]
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[[Category: Muscle protein]]
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[[Category: Myosin]]
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[[Category: Nucleotide-binding]]
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[[Category: Off-state]]
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[[Category: Regulated myosin]]
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[[Category: Scallop regulatory domain/lever arm]]
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[[Category: Smooth and molluscan muscle]]
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[[Category: Thick filament]]
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[[Category: X-ray crystallographic structure]]
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Current revision

Calcium-free Scallop Myosin Regulatory Domain with ELC-D19A Point Mutation

PDB ID 3jtd

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