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3jw1

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{{Seed}}
 
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[[Image:3jw1.jpg|left|200px]]
 
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==Crystal Structure of Bovine Pancreatic Ribonuclease Complexed with Uridine-5'-monophosphate at 1.60 A Resolution==
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The line below this paragraph, containing "STRUCTURE_3jw1", creates the "Structure Box" on the page.
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<StructureSection load='3jw1' size='340' side='right'caption='[[3jw1]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3jw1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JW1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
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{{STRUCTURE_3jw1| PDB=3jw1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jw1 OCA], [https://pdbe.org/3jw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jw1 RCSB], [https://www.ebi.ac.uk/pdbsum/3jw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jw1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/3jw1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jw1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bovine pancreatic ribonuclease A (RNase A) was crystallized from a mixture of small molecules containing basic fuchsin, tobramycin and uridine 5'-monophosphate (U5P). Solution of the crystal structure revealed that the enzyme was selectively bound to U5P, with the pyrimidine ring of U5P residing in the pyrimidine-binding site at Thr45. The structure was refined to an R factor of 0.197 and an R(free) of 0.253.
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===Crystal Structure of Bovine Pancreatic Ribonuclease Complexed with Uridine-5'-monophosphate at 1.60 A Resolution===
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Structure of bovine pancreatic ribonuclease complexed with uridine 5'-monophosphate at 1.60 A resolution.,Larson SB, Day JS, Nguyen C, Cudney R, McPherson A Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Feb 1;66(Pt, 2):113-20. Epub 2010 Jan 26. PMID:20124705<ref>PMID:20124705</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3jw1" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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3JW1 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JW1 OCA].
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:17327668</ref><ref group="xtra">PMID:17101277</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Pancreatic ribonuclease]]
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[[Category: Large Structures]]
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[[Category: CHTSB, Center for High-Throughput Structural Biology.]]
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[[Category: Cudney R]]
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[[Category: Cudney, R.]]
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[[Category: Day JS]]
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[[Category: Day, J S.]]
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[[Category: Larson SB]]
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[[Category: Larson, S B.]]
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[[Category: Mcpherson A]]
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[[Category: Mcpherson, A.]]
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[[Category: Nguyen C]]
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[[Category: Nguyen, C.]]
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[[Category: Center for high-throughput structural biology]]
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[[Category: Chtsb]]
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[[Category: Endonuclease]]
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[[Category: Glycation]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Nuclease]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Ribonuclease some]]
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[[Category: Secreted]]
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[[Category: Structural genomic]]
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[[Category: Uridine-5'-monophosphate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 7 14:14:47 2009''
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Current revision

Crystal Structure of Bovine Pancreatic Ribonuclease Complexed with Uridine-5'-monophosphate at 1.60 A Resolution

PDB ID 3jw1

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