We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

3k6p

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:10, 6 September 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Estrogen Related Receptor alpha in Complex with an Ether Based Ligand==
==Estrogen Related Receptor alpha in Complex with an Ether Based Ligand==
-
<StructureSection load='3k6p' size='340' side='right' caption='[[3k6p]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+
<StructureSection load='3k6p' size='340' side='right'caption='[[3k6p]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3k6p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K6P FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3k6p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K6P FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5FB:4-(4-{[(5R)-2,4-DIOXO-1,3-THIAZOLIDIN-5-YL]METHYL}-2-METHOXYPHENOXY)-3-(TRIFLUOROMETHYL)BENZONITRILE'>5FB</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.996&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ERR1, ESRL1, ESRRA, NR3B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5FB:4-(4-{[(5R)-2,4-DIOXO-1,3-THIAZOLIDIN-5-YL]METHYL}-2-METHOXYPHENOXY)-3-(TRIFLUOROMETHYL)BENZONITRILE'>5FB</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k6p RCSB], [http://www.ebi.ac.uk/pdbsum/3k6p PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6p OCA], [https://pdbe.org/3k6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k6p RCSB], [https://www.ebi.ac.uk/pdbsum/3k6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6p ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ERR1_HUMAN ERR1_HUMAN] Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism.<ref>PMID:9271417</ref> <ref>PMID:12522104</ref> <ref>PMID:16150865</ref> <ref>PMID:17676930</ref> <ref>PMID:18063693</ref>
==See Also==
==See Also==
-
*[[Estrogen-related receptor|Estrogen-related receptor]]
+
*[[Estrogen-related receptor 3D structures|Estrogen-related receptor 3D structures]]
 +
== References ==
 +
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Abad, M C]]
+
[[Category: Large Structures]]
-
[[Category: Patch, R J]]
+
[[Category: Abad MC]]
-
[[Category: Dna-binding]]
+
[[Category: Patch RJ]]
-
[[Category: Estrogen related receptor alpha]]
+
-
[[Category: Hormone receptor]]
+
-
[[Category: Isopeptide bond]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Receptor]]
+
-
[[Category: Transcription]]
+
-
[[Category: Transcription regulation]]
+
-
[[Category: Zinc-finger]]
+

Current revision

Estrogen Related Receptor alpha in Complex with an Ether Based Ligand

PDB ID 3k6p

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3k6p"
Personal tools