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3k7w

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==Protein phosphatase 2A core complex bound to dinophysistoxin-2==
==Protein phosphatase 2A core complex bound to dinophysistoxin-2==
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<StructureSection load='3k7w' size='340' side='right' caption='[[3k7w]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
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<StructureSection load='3k7w' size='340' side='right'caption='[[3k7w]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3k7w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K7W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K7W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3k7w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K7W FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XT2:(2R)-2-HYDROXY-3-[(2S,5R,6R,8S)-5-HYDROXY-8-{(1R,2E)-3-[(2R,4AR,5R,6S,8R,8AS)-8-HYDROXY-6-{(1S,3S)-1-HYDROXY-3-[(2S,6R,11S)-11-METHYL-1,7-DIOXASPIRO[5.5]UNDEC-2-YL]BUTYL}-7-METHYLIDENEOCTAHYDRO-3H,3H-SPIRO[FURAN-2,2-PYRANO[3,2-B]PYRAN]-5-YL]-1-METHYLPROP-2-EN-1-YL}-10-METHYL-1,7-DIOXASPIRO[5.5]UNDEC-10-EN-2-YL]-2-METHYLPROPANOIC+ACID'>XT2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.96&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ie4|2ie4]], [[3k7v|3k7v]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XT2:(2R)-2-HYDROXY-3-[(2S,5R,6R,8S)-5-HYDROXY-8-{(1R,2E)-3-[(2R,4AR,5R,6S,8R,8AS)-8-HYDROXY-6-{(1S,3S)-1-HYDROXY-3-[(2S,6R,11S)-11-METHYL-1,7-DIOXASPIRO[5.5]UNDEC-2-YL]BUTYL}-7-METHYLIDENEOCTAHYDRO-3H,3H-SPIRO[FURAN-2,2-PYRANO[3,2-B]PYRAN]-5-YL]-1-METHYLPROP-2-EN-1-YL}-10-METHYL-1,7-DIOXASPIRO[5.5]UNDEC-10-EN-2-YL]-2-METHYLPROPANOIC+ACID'>XT2</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPP2R1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), PPP2CA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k7w OCA], [https://pdbe.org/3k7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k7w RCSB], [https://www.ebi.ac.uk/pdbsum/3k7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k7w ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k7w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k7w RCSB], [http://www.ebi.ac.uk/pdbsum/3k7w PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/2AAA_HUMAN 2AAA_HUMAN]] The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.<ref>PMID:16580887</ref> [[http://www.uniprot.org/uniprot/PP2AA_HUMAN PP2AA_HUMAN]] PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.<ref>PMID:9920888</ref> <ref>PMID:10801873</ref> <ref>PMID:22613722</ref>
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[https://www.uniprot.org/uniprot/2AAA_HUMAN 2AAA_HUMAN] The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.<ref>PMID:16580887</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/3k7w_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/3k7w_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k7w ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3k7w" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Protein phosphatase|Protein phosphatase]]
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*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
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*[[Serine/threonine protein phosphatase|Serine/threonine protein phosphatase]]
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphoprotein phosphatase]]
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[[Category: Large Structures]]
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[[Category: Huhn, J]]
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[[Category: Huhn J]]
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[[Category: Jeffrey, P D]]
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[[Category: Jeffrey PD]]
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[[Category: Shi, Y]]
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[[Category: Shi Y]]
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[[Category: Centromere]]
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[[Category: Cytoskeleton]]
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[[Category: Heat repeat]]
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[[Category: Hydrolase]]
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[[Category: Iron]]
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[[Category: Ligand specificity]]
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[[Category: Manganese]]
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[[Category: Metal-binding]]
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[[Category: Methylation]]
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[[Category: Nucleus]]
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[[Category: Phosphatase]]
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[[Category: Phosphoprotein]]
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[[Category: Protein phosphatase]]
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[[Category: Protein-protein complex]]
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[[Category: Signaling protein]]
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[[Category: Signaling protein-hydrolase complex]]
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Current revision

Protein phosphatase 2A core complex bound to dinophysistoxin-2

PDB ID 3k7w

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