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3k9v
From Proteopedia
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==Crystal structure of rat mitochondrial P450 24A1 S57D in complex with CHAPS== | ==Crystal structure of rat mitochondrial P450 24A1 S57D in complex with CHAPS== | ||
| - | <StructureSection load='3k9v' size='340' side='right' caption='[[3k9v]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='3k9v' size='340' side='right'caption='[[3k9v]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3k9v]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3k9v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K9V FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k9v OCA], [https://pdbe.org/3k9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k9v RCSB], [https://www.ebi.ac.uk/pdbsum/3k9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k9v ProSAT]</span></td></tr> | |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </table> |
| - | <table> | + | == Function == |
| + | [https://www.uniprot.org/uniprot/CP24A_RAT CP24A_RAT] Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/3k9v_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/3k9v_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k9v ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism.,Annalora AJ, Goodin DB, Hong WX, Zhang Q, Johnson EF, Stout CD J Mol Biol. 2010 Feb 19;396(2):441-51. Epub 2009 Dec 1. PMID:19961857<ref>PMID:19961857</ref> | Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism.,Annalora AJ, Goodin DB, Hong WX, Zhang Q, Johnson EF, Stout CD J Mol Biol. 2010 Feb 19;396(2):441-51. Epub 2009 Dec 1. PMID:19961857<ref>PMID:19961857</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | <div class="pdbe-citations 3k9v" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Annalora | + | [[Category: Annalora AJ]] |
| - | [[Category: Goodin | + | [[Category: Goodin DB]] |
| - | [[Category: Hong | + | [[Category: Hong W]] |
| - | [[Category: Johnson | + | [[Category: Johnson EF]] |
| - | [[Category: Stout | + | [[Category: Stout CD]] |
| - | [[Category: Zhang | + | [[Category: Zhang Q]] |
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Current revision
Crystal structure of rat mitochondrial P450 24A1 S57D in complex with CHAPS
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