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3kuz

From Proteopedia

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[[Image:3kuz.png|left|200px]]
 
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{{STRUCTURE_3kuz| PDB=3kuz | SCENE= }}
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==Crystal structure of the ubiquitin like domain of PLXNC1==
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<StructureSection load='3kuz' size='340' side='right'caption='[[3kuz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===Crystal structure of the ubiquitin like domain of PLXNC1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3kuz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KUZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[3kuz]] is a 2 chain structure of [[Plexin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUZ OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kuz OCA], [https://pdbe.org/3kuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kuz RCSB], [https://www.ebi.ac.uk/pdbsum/3kuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kuz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PLXC1_HUMAN PLXC1_HUMAN] Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).<ref>PMID:20727575</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/3kuz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kuz ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Plexin|Plexin]]
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*[[Plexin 3D structures|Plexin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bochkarev A]]
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[[Category: Buck, M.]]
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[[Category: Bountra C]]
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[[Category: Crombet, L.]]
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[[Category: Buck M]]
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[[Category: Edwards, A M.]]
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[[Category: Crombet L]]
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[[Category: Guan, X.]]
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[[Category: Edwards AM]]
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[[Category: Li, B.]]
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[[Category: Guan X]]
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[[Category: MacKenzie, F.]]
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[[Category: Li B]]
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[[Category: Park, H.]]
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[[Category: MacKenzie F]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Park H]]
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[[Category: Tempel, W.]]
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[[Category: Tempel W]]
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[[Category: Tong, Y.]]
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[[Category: Tong Y]]
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[[Category: Wang, H.]]
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[[Category: Wang H]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Zhong, N.]]
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[[Category: Zhong N]]
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[[Category: Plexin]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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Current revision

Crystal structure of the ubiquitin like domain of PLXNC1

PDB ID 3kuz

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